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Electrophoretic deposition of lawsone loaded bioactive glass (BG)/chitosan composite on polyetheretherketone (PEEK)/BG layers as antibacterial and bioactive coating

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dc.contributor.authors Rehman, MAU; Bastan, FE; Nawaz, Q; Goldmann, WH; Maqbool, M; Virtanen, S; Boccaccini, AR;
dc.date.accessioned 2020-10-16T11:08:50Z
dc.date.available 2020-10-16T11:08:50Z
dc.date.issued 2018
dc.identifier.citation Rehman, MAU; Bastan, FE; Nawaz, Q; Goldmann, WH; Maqbool, M; Virtanen, S; Boccaccini, AR; (2018). Electrophoretic deposition of lawsone loaded bioactive glass (BG)/chitosan composite on polyetheretherketone (PEEK)/BG layers as antibacterial and bioactive coating. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 106, 3122-3111
dc.identifier.issn 1549-3296
dc.identifier.uri https://doi.org/10.1002/jbm.a.36506
dc.identifier.uri https://hdl.handle.net/20.500.12619/69750
dc.description.abstract In this study, chitosan/bioactive glass (BG)/lawsone coatings were deposited by electrophoretic deposition (EPD) on polyetheretherketone (PEEK)/BG layers (previously deposited by EPD on 316-L stainless steel) to produce bioactive and antibacterial coatings. First, the EPD of chitosan/BG/lawsone was optimized on stainless steel in terms of suspension stability, homogeneity and thickness of coatings. Subsequently, the optimized EPD parameters were used to produce bioresorbable chitosan/bioactive glass (BG)/lawsone coatings on PEEK/BG layers. The produced layered coatings were characterized in terms of composition, microstructure, corrosion resistance, in vitro bioactivity, drug release kinetics and antibacterial activity. Ultraviolet/Visible (UV/VIS) spectroscopic analyses confirmed the release of lawsone from the coatings. Moreover, the deposition of chitosan/BG coatings was confirmed by Scanning Electron Microscopy (SEM) and Fourier Transform Infrared spectroscopy (FTIR). The coated specimens presented higher corrosion resistance (10 times) in comparison to that of bare 316-L stainless steel and showed convenient wettability for initial protein attachment. The presence of lawsone in the top layer provided antibacterial effects against Staphylococcus carnosus. Moreover, the developed coatings formed apatite-like crystals upon immersion in simulated body fluid, indicating the possibility of achieving close interaction between the coating surface and bone. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3111-3122, 2018.
dc.language English
dc.publisher WILEY
dc.subject Materials Science
dc.title Electrophoretic deposition of lawsone loaded bioactive glass (BG)/chitosan composite on polyetheretherketone (PEEK)/BG layers as antibacterial and bioactive coating
dc.type Article
dc.identifier.volume 106
dc.identifier.startpage 3111
dc.identifier.endpage 3122
dc.contributor.department Sakarya Üniversitesi/Mühendislik Fakültesi/Metalurji Ve Malzeme Mühendisliği Bölümü
dc.contributor.saüauthor Baştan, Fatih Erdem
dc.relation.journal JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
dc.identifier.wos WOS:000450308200011
dc.identifier.doi 10.1002/jbm.a.36506
dc.identifier.eissn 1552-4965
dc.contributor.author Muhammad Atiq Ur Rehman
dc.contributor.author Baştan, Fatih Erdem
dc.contributor.author Qaisar Nawaz
dc.contributor.author Wolfgang H. Goldmann
dc.contributor.author Muhammad Maqbool
dc.contributor.author Sannakaisa Virtanen
dc.contributor.author Aldo R. Boccaccini


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