Açık Akademik Arşiv Sistemi

3D porous collagen/functionalized multiwalled carbon nanotube/chitosan/hydroxyapatite composite scaffolds for bone tissue engineering

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dc.contributor.authors Turk, S; Altinsoy, I; Efe, GC; Ipek, M; Ozacar, M; Bindal, C;
dc.date.accessioned 2020-10-16T11:08:49Z
dc.date.available 2020-10-16T11:08:49Z
dc.date.issued 2018
dc.identifier.citation Turk, S; Altinsoy, I; Efe, GC; Ipek, M; Ozacar, M; Bindal, C; (2018). 3D porous collagen/functionalized multiwalled carbon nanotube/chitosan/hydroxyapatite composite scaffolds for bone tissue engineering. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 92, 768-757
dc.identifier.issn 0928-4931
dc.identifier.uri https://doi.org/10.1016/j.msec.2018.07.020
dc.identifier.uri https://hdl.handle.net/20.500.12619/69730
dc.description.abstract In this study, we describe new collagen/functionalized multiwalled carbon nanotube/chitosan/hydroxyapatite (Col/f-MWCNT/CS/HA) composite scaffolds which were fabricated by freezing ( - 40 degrees C at 0.9 degrees C/min) and lyophilization (48 h, 0 degrees C and 200 mtorr). The compressive stresses (from 523 to 1112 kPa), swelling (from 513.9 +/- 27 to 481.05 +/- 25%), porosity (from 98 +/- 0.15 to 95.7 +/- 0.1%), contact angle (from 87.8 to 76.7 degrees) properties examined before and after biomineralization for comparison 3D porous Col, CS, Col/f-MWCNT and Col/f-MWCNT/CS scaffolds. Biomineralization was performed by biomimetic method in concentrated SBF (10 x SBF, at 37 degrees C and 6.5 pH). XRD, SEM, EDS, FTIR, TGA, Optical microscopy and BET results showed that compared to Col, CS and Col/f-MWCNT scaffolds, Col/f-MWCNT/CS scaffolds had higher in vitro bioactivity, large surface area (11.746 m(2)/g) and a good pore volume (0.026 cc/g), interconnected porous microstructure (with 20-350 mu m pore size) and incorporates the advantageous properties of both Col, f-MWCNT, CS and HA. Finally, the methyl thiazolyl tetrazolium (MTT) assay was performed to evaluate scaffolds cytotoxicity which showed that Col/f-MWCNT/CS scaffolds have the best biocompatibility.
dc.language English
dc.publisher ELSEVIER SCIENCE BV
dc.subject Materials Science
dc.title 3D porous collagen/functionalized multiwalled carbon nanotube/chitosan/hydroxyapatite composite scaffolds for bone tissue engineering
dc.type Article
dc.identifier.volume 92
dc.identifier.startpage 757
dc.identifier.endpage 768
dc.contributor.department Sakarya Üniversitesi/Biyomedikal, Manyetik Ve Yarıiletken Malzemeler Araştırma Merkezi
dc.contributor.saüauthor Türk, Serbülent
dc.contributor.saüauthor Altınsoy, İbrahim
dc.contributor.saüauthor Çelebi Efe, Gözde Fatma
dc.contributor.saüauthor İpek, Mümtaz
dc.contributor.saüauthor Özacar, Mahmut
dc.contributor.saüauthor Bindal, Cuma
dc.relation.journal MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
dc.identifier.wos WOS:000445309700077
dc.identifier.doi 10.1016/j.msec.2018.07.020
dc.identifier.eissn 1873-0191
dc.contributor.author Türk, Serbülent
dc.contributor.author Altınsoy, İbrahim
dc.contributor.author Çelebi Efe, Gözde Fatma
dc.contributor.author İpek, Mümtaz
dc.contributor.author Özacar, Mahmut
dc.contributor.author Bindal, Cuma


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