Açık Akademik Arşiv Sistemi

Six-year distribution pattern of hepatitis C virus in Turkey: a multicentre study

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dc.contributor.authors Altindis, M; Dal, T; Akyar, I; Karatuna, O; Gokahmetoglu, S; Ulger, ST; Kulah, C; Uzun, B; Sener, AG; Ozdemir, M; Aydogan, S; Kuskucu, MA; Midilli, K; Otlu, B; Celen, MK; Buruk, K; Guducuoglu, H;
dc.date.accessioned 2020-02-24T13:47:57Z
dc.date.available 2020-02-24T13:47:57Z
dc.date.issued 2016
dc.identifier.citation Altindis, M; Dal, T; Akyar, I; Karatuna, O; Gokahmetoglu, S; Ulger, ST; Kulah, C; Uzun, B; Sener, AG; Ozdemir, M; Aydogan, S; Kuskucu, MA; Midilli, K; Otlu, B; Celen, MK; Buruk, K; Guducuoglu, H; (2016). Six-year distribution pattern of hepatitis C virus in Turkey: a multicentre study. BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, 30, 340-335
dc.identifier.issn 1310-2818
dc.identifier.uri https://doi.org/10.1080/13102818.2015.1093430
dc.identifier.uri https://hdl.handle.net/20.500.12619/44519
dc.description.abstract Hepatitis C infection is a public health problem. The aim of this retrospective study was to determine the distribution of hepatitis C virus (HCV) genotypes in seven regions of Turkey, by evaluating 7002 patients with chronic HCV in a six-year period. During the 2009-2014 period, serum/plasma samples from 7002 new consecutive HCV RNA positive patients were collected. The female patients were 3867 (55.2%). The genotype distribution of HCV patiens was evaluated by ages and years. Statistical analysis was performed by using the Mann-Whitney test and the chi(2) analysis. During the six-year period, genotype 1b was the most common genotype (67.7%) followed by untypeable genotype 1 (7.7%), genotype 4 (7.3%) and genotype 3 (6.7%). In 2014, genotype 3 was the second most common one (11.3%) and genotype 4 was the third most common one (9.8%). In the group with <25 years old patients, genotype 1b was most common (78.48%, 62/79) between the years of 2009 and 2011, whereas genotype 3 (34.8%, 86/247), between the years of 2012 and 2014. Genotype 1b was the most common in the groups between 26 and 35 years, 36 and 45 years, 46 and 55 years, 56 and 65 years. The rate of genotype 3 was increased from 4.78% to 10.06% and the rate of genotype 4 was increased from 1.3% to 3.84%, from 2009-2011 to 2012-2014. In recent years, genotypes 3 and 4 have gained importance. New therapeutic strategies and survey studies may be required for the modified HCV genotype pattern.
dc.language English
dc.publisher TAYLOR & FRANCIS LTD
dc.subject Biotechnology & Applied Microbiology
dc.title Six-year distribution pattern of hepatitis C virus in Turkey: a multicentre study
dc.type Article
dc.identifier.volume 30
dc.identifier.startpage 335
dc.identifier.endpage 340
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü
dc.contributor.saüauthor Altındiş, Mustafa
dc.contributor.saüauthor Özdemir, Mehmet
dc.relation.journal BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
dc.identifier.wos WOS:000372200700018
dc.identifier.doi 10.1080/13102818.2015.1093430
dc.identifier.eissn 1314-3530
dc.contributor.author Altındiş, Mustafa
dc.contributor.author Tuba Dal
dc.contributor.author Isin Akyar
dc.contributor.author Onur Karatuna
dc.contributor.author Selma Gokahmetoglu
dc.contributor.author Seda Tezcan Ulger
dc.contributor.author Canan Kulah
dc.contributor.author Berrin Uzun
dc.contributor.author Asli Gamze Sener
dc.contributor.author Özdemir, Mehmet
dc.contributor.author Sibel Aydogan
dc.contributor.author Mert Ahmet Kuskucu
dc.contributor.author Kenan Midilli
dc.contributor.author Baris Otlu
dc.contributor.author Mustafa Kemal Celen
dc.contributor.author Kurtulus Buruk
dc.contributor.author Huseyin Guducuoglu


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