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Asymmetric reduction of substituted acetophenones using once Rhodotorula glutinis cells immobilized

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dc.contributor.authors Kurbanoglu, EB; Zilbeyaz, K; Ozdal, M; Taskin, M; Kurbanoglu, NI;
dc.date.accessioned 2020-02-24T13:29:08Z
dc.date.available 2020-02-24T13:29:08Z
dc.date.issued 2010
dc.identifier.citation Kurbanoglu, EB; Zilbeyaz, K; Ozdal, M; Taskin, M; Kurbanoglu, NI; (2010). Asymmetric reduction of substituted acetophenones using once Rhodotorula glutinis cells immobilized. BIORESOURCE TECHNOLOGY, 101, 3829-3825
dc.identifier.issn 0960-8524
dc.identifier.uri https://doi.org/10.1016/j.biortech.2010.01.016
dc.identifier.uri https://hdl.handle.net/20.500.12619/44215
dc.description.abstract The asymmetric reductions of acetophenone and its analogues using once immobilized Rhodotorula glutinis cells were studied. The performance and reaction parameters of the immobilized cells were also investigated and it was determined that the cells could be used 15 times in batch processes. All chiral alcohols obtained using purification procedures were of sufficient enantiopurity (>99%) of the (S)-enantiomer. The applicability of the optimized process for a preparative scale bioreduction was shown. Under the optimum conditions, 35 mM (4.3 g) of the product ((S)-1-phenylethanol) was produced from 45 mM (5.4 g) of the substrate (acetophenone) with one time immobilized R. glutinis EBK-2 cells (6 g wet weight). The yield was calculated as 77%. In this study, it was found that the buffer level had a very significant effect on the reaction activity. Our results demonstrate that the optimized process can be implemented on a preparative scale. (C) 2010 Elsevier Ltd. All rights reserved.
dc.language English
dc.publisher ELSEVIER SCI LTD
dc.subject Energy & Fuels
dc.title Asymmetric reduction of substituted acetophenones using once Rhodotorula glutinis cells immobilized
dc.type Article
dc.identifier.volume 101
dc.identifier.startpage 3825
dc.identifier.endpage 3829
dc.contributor.department Sakarya Üniversitesi/Mühendislik Fakültesi/Endüstri Mühendisliği Bölümü
dc.contributor.saüauthor Taşkın, Mehmet Fatih
dc.contributor.saüauthor Kurbanoğlu, Namudar İzzet
dc.relation.journal BIORESOURCE TECHNOLOGY
dc.identifier.wos WOS:000275999800004
dc.identifier.doi 10.1016/j.biortech.2010.01.016
dc.contributor.author Taşkın, Mehmet Fatih
dc.contributor.author Kurbanoğlu, Namudar İzzet


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