Asymmetric reduction of acetophenone analogues by Alternaria alternata using ram horn peptone

Abstract

Alternaria alternata EBK-4 fungus isolated from a plant sample was evaluated for the asymmetric reduction of acetophenone analogues. In a previous study, this isolate was used for the reduction of acetophenone to 1-phenylethanol in excellent enantiomeric excess. The substituted acetophenones were converted to the corresponding optically active alcohol by A. alternata EBK-4 under optimized conditions in up to > 99% enantiomeric excess (ee). This is the. rst report on the enantiomeric reduction of acetophenone analogues by A. alternata using ram horn peptone from waste material. (c) 2007 Elsevier Ltd. All rights reserved.