Bazı anti-enflamatuar ilaçların yük transfer komplekslerinin incelenmesi

Abstract

ÖZET Anahtar Kelimeler : Elektron donör akseptör kompleksleri, antienflamatuar, TCNE, DDQ,p~Kloranil, Etofenomat, Etodolak ve Naproxen. Bu çalışmanın amacı antienflamatuar ilaçlar olan Etofenomat, Etodolak ve Naproksen'in electron donör akseptör komplekslerini nasıl oluşturduğunu incelemektir. Elektron akseptörler olan TCNE, DDQ ve p-Kloraml ile elektron donörler olan Etofenomat, Etodolak ve Naproksen'in elektron donör akseptör kompleksleri spektrofotometrik olarak incelendi. Kompleks stokiometrileri Job Metodu, komplekslerin denge sabitleri Benesi-Hildebrand denklemi ve termodinamik sabitleri Van't Hoff denklemi ile hesaplandı. Etofenomat - TCNE kompleksi 670 nm de maksimum absorpsiyon verdi. Kompleksin denge sabiti 2,219 Lmol"1, termodinamik sabitleri AH: -769,6 cal mol"1, AS: -10,10 cal mol"1 ve AG °: -465,64 cal mol"1 dir. Etodolak - TCNE kompleksi 597 nm de maksimum absorpsiyon verdi. Kompleksin denge sabiti 0,775 Lmol"1, termodinamik sabitleri AH: -2752,2 cal mol"1, AS: -12,01 cal mol"1 ve AG °: 150,4 cal mol'1 dir. Naproksen - TCNE kompleksi 611 nm de maksimum absorpsiyon verdi. Kompleksin denge sabiti 0,721 Lmol"1, termodinamik sabitleri AH: -891 cal mol"1, AS: -9,25 cal mol"1 ve AG °: 192 cal mol"1 dir. Etofenomat - DDQ kompleksi 763 nm de maksimum absorpsiyon verdi. Kompleksin denge sabiti 6,2 Lmol"1, termodinamik sabitleri AH: -3660 cal mol"1, AS: -14,5 cal mol"1 ve AG °: -1065,91 cal mol"1 dir. Naproksen - DDQ kompleksi 703 nm de maksimum absorpsiyon verdi. Kompleksin denge sabiti 6,53 Lmol", termodinamik sabitleri AH: -2378 cal mol"1, AS: -13,46 cal mol"1 ve AG °: -1 105 cal mol"1 dir. Etofenomat -/»-Kloranil kompleksi 575 nm de maksimum absorpsiyon verdi. Kompleksin denge sabiti 2,54 Lmol"1, termodinamik sabitleri AH: -1548 cal mol"1, AS: -14,85 cal mol"1 ve AG °: -546,4 cal mol"1 dir. Etodolak - p-Kloranil kompleksi 536 nm de maksimum absorpsiyon verdi. Kompleksin denge sabiti 5,45 Lmol"1, termodinamik sabitleri AH: -1336 cal mol"1, AS: -9,88 cal mol"1 ve AG °: -993,94 cal mol"1 dir. Naproksen -p-Kloranil kompleksi 554 nm de maksimum absorpsiyon verdi. Kompleksin denge sabiti 5,4 Lmol"1, termodinamik sabitleri AH: -1048 cal mol"1, AS: -11,74 cal mol"1 ve AG °: -985,2 cal mol"1 dir. XII

EXAMINING CHARGE TRANSFER COMPLEXES OF SOME ANTİ-İNFLAMATORY DRUGS SUMMARY Keywords : Electron donor acceptor complexes, anti-inflammatory, TCNE, DDQ, p-Chloranil, Etofenomat, Etodolac, Naproxene. The purpose of this study is to examine how Etofenomat, Etodolac and Naproxene which are anti-inflamatory drugs form electron donor acceptor complexes. Electron donor acceptor complexes of Etofenomat, Etodolac, Naproxene as electron donors with TCNE, DDQ, /7-Chloranil as electron acceptors have been examined spectrophotometricly. Stoichiometries of the complexes were calculated by Job's method. Equilibrium constants of the complexes were calculated by Benesi- Hildebrand equation. Thermodynamic constants of the complexes were calculated by Van't Hoff equation. EDA complexes of Etofenomat - TCNE gave a maximum absorption at 670 nm. Equilibrium constant of the complex is 2,219 L mole"1, thermodynamic constants of the complex; AH: -769,6 cal mole"1, AS: -10,10 cal mole"1 and AG °: -465,64 cal mole"1. EDA complexes of Etodolac - TCNE gave a maximum absorption at 597 nm. Equilibrium constant of the complex is 0,775 L mole"1, thermodynamic constants of the complex; AH: -2752,2 cal mole"1, AS: -12,01 cal mole"1 and AG °: 150,4 cal mole"1. EDA complexes of Naproxene - TCNE gave a maximum absorption at 611 nm. Equilibrium constant of the complex is 0,721 L mole"1, thermodynamic constants of the complex; AH: -891 cal mole"1, AS: -9,25 cal mole"1 and AG °: 192 cal mole"1. EDA complexes of Etofenomat - DDQ gave a maximum absorption at 763 nm. Equilibrium constant of the complex is 6,2 L mole"1, thermodynamic constants of the complex; AH: -3660 cal mole"1, AS: -14,5 cal mole"1 and AG °: -1065,91 cal mole"1. EDA complexes of Naproxene - DDQ gave a maximum absorption at 703 nm. Equilibrium constant of the complex is 6,53 L mole"1, thermodynamic constants of the complex; AH:-2378 cal mole"1, AS:-13,46 cal mole"1 and AG °: -1105 cal mole"1. EDA complexes of Etofenomat - /7-Chloranil gave a maximum absorption at 575 nm. Equilibrium constant of the complex is 2,54 L mole"1, thermodynamic constants of the complex; AH: -1548 cal mole"1, AS: -14,85 cal mole"1 and AG °: -546,4 cal mole"1. EDA complexes of Etodolac - /7-Chloranil gave a maximum absorption at 536 nm. Equilibrium constant of the complex is 5,45 L mole"1, thermodynamic constants of the complex; AH: -1336 cal mole, AS: -9,88 cal mole"1 and AG °: -993,94 cal mole"1. EDA complexes of Naproxene -/?-Chloranil gave a maximum absorption at 554 nm. Equilibrium constant of the complex is 5,4 L mole"1, thermodynamic constants of the complex; AH: -1048 cal mole"1, AS: -11,74 cal mole"1 and AG °: -985,2 cal mole"1. xm