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The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture

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dc.contributor.authors Aydemir, B; Akdemir, R; Vatan, MB; Cinemre, FB; Cinemre, H; Kiziler, AR; Bahtiyar, N; Buyukokuroglu, ME; Gurol, G; Ogut, S;
dc.date.accessioned 2020-02-27T08:45:00Z
dc.date.available 2020-02-27T08:45:00Z
dc.date.issued 2015
dc.identifier.citation Aydemir, B; Akdemir, R; Vatan, MB; Cinemre, FB; Cinemre, H; Kiziler, AR; Bahtiyar, N; Buyukokuroglu, ME; Gurol, G; Ogut, S; (2015). The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture. BIOLOGICAL TRACE ELEMENT RESEARCH, 167, 186-179
dc.identifier.issn 0163-4984
dc.identifier.uri https://doi.org/10.1007/s12011-015-0307-6
dc.identifier.uri https://hdl.handle.net/20.500.12619/66839
dc.description.abstract Chordae tendineae rupture process is associated with increased production of inflammatory and angiogenesis mediators in connective tissues, which contributes to chronic inflammation and pathogenesis of degenerative chordae. A few trace elements are known to possess antioxidant, anti-inflammatory, and antiangiogenic properties. Therefore, the aim of this study was to determine whether zinc, selenium, midkine (MK), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), vascular endothelial growth factor-A (VEGF-A), platelet-derived growth factor-BB (PDGF-BB), and reduced glutathione (GSH) levels are associated with inflammation and angiogenesis processes in the context of a potential etiology causing aggravation of mitral regurgitation and/or ruptured chordae tendineae. Seventy-one subjects comprising 34 patients with mitral chordae tendineae rupture (MCTR) and 37 healthy controls diagnosed on the basis of their clinical profile and transthoracic echocardiography were included in this study. The levels of GSH, MK, selenium, and zinc were found to be lower in the patients group when compared to control group. There were no significant difference in plasma TNF-alpha, IL-1 beta, IL-6, IL-8, VEGF-A, and PDGF-BB levels between two groups. There were positive significant correlations between MK and GSH, MK, and selenium levels in patients with MCTR. According to our data in which selenium, zinc, MK, and GSH decreased in MCTR patients, inflammatory response, oxidative stress, and trace element levels may contribute to etiopathogenesis of mitral regurgitation and/or ruptured chordae tendineae.
dc.language English
dc.publisher HUMANA PRESS INC
dc.subject Endocrinology & Metabolism
dc.title The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture
dc.type Article
dc.identifier.volume 167
dc.identifier.startpage 179
dc.identifier.endpage 186
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü
dc.contributor.saüauthor Aydemir, Birsen
dc.contributor.saüauthor Akdemir, Ramazan
dc.contributor.saüauthor Vatan, Mehmet Bülent
dc.contributor.saüauthor Cinemre, Fatma Behice
dc.contributor.saüauthor Cinemre, Hakan
dc.contributor.saüauthor Büyükokuroğlu, Mehmet Emin
dc.contributor.saüauthor Gürol Çiftci, Gönül
dc.relation.journal BIOLOGICAL TRACE ELEMENT RESEARCH
dc.identifier.wos WOS:000362282000003
dc.identifier.doi 10.1007/s12011-015-0307-6
dc.identifier.eissn 1559-0720
dc.contributor.author Aydemir, Birsen
dc.contributor.author Akdemir, Ramazan
dc.contributor.author Vatan, Mehmet Bülent
dc.contributor.author Cinemre, Fatma Behice
dc.contributor.author Cinemre, Hakan
dc.contributor.author Büyükokuroğlu, Mehmet Emin
dc.contributor.author Gürol Çiftci, Gönül


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