Açık Akademik Arşiv Sistemi

Regressive course of oxalate deposition in primary hyperoxaluria after kidney transplantation

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dc.contributor.authors Celik, G; Sen, S; Sipahi, S; Akkin, C; Tamsel, S; Toz, H; Hoscoskun, C;
dc.date.accessioned 2020-02-27T08:32:35Z
dc.date.available 2020-02-27T08:32:35Z
dc.date.issued 2010
dc.identifier.citation Celik, G; Sen, S; Sipahi, S; Akkin, C; Tamsel, S; Toz, H; Hoscoskun, C; (2010). Regressive course of oxalate deposition in primary hyperoxaluria after kidney transplantation. RENAL FAILURE, 32, 1136-1131
dc.identifier.issn 0886-022X
dc.identifier.uri https://doi.org/10.3109/0886022X.2010.509900
dc.identifier.uri https://hdl.handle.net/20.500.12619/66345
dc.description.abstract Primary hyperoxaluria (PH) is a rare autosomal recessive disease caused by the functional defect of alanine-glyoxylate aminotransferase (AGT) enzyme in the liver and it is characterized by the deposition of diffuse calcium oxalate crystals. A 38-year-old male patient presented with history of recurrent nephrolithiasis and has received chronic hemodialysis treatment for 2 years. Cadaveric renal transplantation was applied to the case. The patient was reoperated on postoperative day 13 because of the collection surrounding the urethra. During this operation, kidney biopsy was made due to late decrease in creatinine levels. Deposition of diffuse oxalate crystal was detected in allograft kidney biopsy, whereas in the 0-hour biopsy there were no oxalate crystals. Oxalate level was found to be high in a 24-hour urine specimen (118 mg/L, normal level: 7-44 mg/L). The patient was identified with primary hyperoxaluria and followed up in terms of systemic oxalate deposition as well as allograft kidney. In the kidney biopsy taken after 18 months, we detected that oxalate crystals almost entirely disappeared. In our case, bilateral preretinal, intraretinal, and intravascular diffuse oxalate crystals were detected, and argon laser photocoagulation treatments were needed for choroidal and retinal neovascularization. Repeated ophthalmic examinations showed the regressive nature of oxalate depositions. In the 18th month, fundus examination and fluorescein angiography revealed that oxalate crystals were significantly regressed. To increase the quality of life and slow down the systemic effects of oxalosis, kidney-only transplantation is beneficial.
dc.language English
dc.publisher INFORMA HEALTHCARE
dc.subject Urology & Nephrology
dc.title Regressive course of oxalate deposition in primary hyperoxaluria after kidney transplantation
dc.type Article
dc.identifier.volume 32
dc.identifier.startpage 1131
dc.identifier.endpage 1136
dc.contributor.department Sakarya Üniversitesi/Mühendislik Fakültesi/Metalurji Ve Malzeme Mühendisliği Bölümü
dc.contributor.saüauthor Şen, Şaduman
dc.contributor.saüauthor Sipahi, Savaş
dc.relation.journal RENAL FAILURE
dc.identifier.wos WOS:000283121700021
dc.identifier.doi 10.3109/0886022X.2010.509900
dc.contributor.author G. Celik
dc.contributor.author Şen, Şaduman
dc.contributor.author Sipahi, Savaş
dc.contributor.author C. Akkin
dc.contributor.author S. Tamsel
dc.contributor.author H. Toz
dc.contributor.author C. Hoscoskun


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