Açık Akademik Arşiv Sistemi

Paraoxonase 1 (PON1) Q192R and L55M polymorphisms, lipid profile, lipid peroxidation and lipoprotein-a levels in Turkish patients with pregnancy-related disorders

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dc.contributor.authors Aydemir, B; Cinemre, FBS; Cinemre, H; Tuten, A; Yuksel, MA; Yilmaz, N; Kaya, B; Akdemir, N; Erdogan, E; Madazli, R;
dc.date.accessioned 2020-02-27T08:29:08Z
dc.date.available 2020-02-27T08:29:08Z
dc.date.issued 2019
dc.identifier.citation Aydemir, B; Cinemre, FBS; Cinemre, H; Tuten, A; Yuksel, MA; Yilmaz, N; Kaya, B; Akdemir, N; Erdogan, E; Madazli, R; (2019). Paraoxonase 1 (PON1) Q192R and L55M polymorphisms, lipid profile, lipid peroxidation and lipoprotein-a levels in Turkish patients with pregnancy-related disorders. GYNECOLOGICAL ENDOCRINOLOGY, 35, 421-417
dc.identifier.issn 0951-3590
dc.identifier.uri https://doi.org/10.1080/09513590.2018.1532990
dc.identifier.uri https://hdl.handle.net/20.500.12619/66117
dc.description.abstract The aim of this study was to investigate the role of PON1Q192R and L55M single nucleotide polymorphisms(SNPs) and its association with the maternal levels of lipid parameters in gestational diabetes mellitus(GDM) and preeclampsia(PE). Ninety-nine pregnant with GDM, 97 pregnant with PE and 98 healthy pregnant were included in the study. No statistically significant difference was observed in the alleles or in the genotypes frequencies of SNPs between groups. In GDM patients, total cholesterol was higher in MM genotype of L55M gene (p < .05); Lp(a) were lower in LM genotype of the gene compared to their respective control (p < .05). In PE, HDL-C levels were higher in LM genotype (p < .05); LDL-C levels were lower in MM genotype of the gene compared to their respective control (p < .05). In PE patients, malondialdehyde(MDA) were higher in QQ genotype compared to their respective control (p < .05). Triglyceride levels were higher in PE patients with QR genotype compared with GDM patients with QR genotype (p < .05). Our results indicated that lipid profiles, Lp(a) and MDA levels showed significant differences in GDM and PE pregnants. These findings support the importance of the lipid profile, oxidized lipid and Lp(a) in different genotypes of L55M and Q192R in Turkish pregnant women with PE/GDM suggesting their roles in etiopathogenesis in these pregnancy-related disorders.
dc.language English
dc.publisher TAYLOR & FRANCIS LTD
dc.subject Obstetrics & Gynecology
dc.title Paraoxonase 1 (PON1) Q192R and L55M polymorphisms, lipid profile, lipid peroxidation and lipoprotein-a levels in Turkish patients with pregnancy-related disorders
dc.type Article
dc.identifier.volume 35
dc.identifier.startpage 417
dc.identifier.endpage 421
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü
dc.contributor.saüauthor Aydemir, Birsen
dc.contributor.saüauthor Cinemre, Fatma Behice
dc.contributor.saüauthor Cinemre, Hakan
dc.contributor.saüauthor Akdemir, Nermin
dc.relation.journal GYNECOLOGICAL ENDOCRINOLOGY
dc.identifier.wos WOS:000467731500010
dc.identifier.doi 10.1080/09513590.2018.1532990
dc.identifier.eissn 1473-0766
dc.contributor.author Aydemir, Birsen
dc.contributor.author Cinemre, Fatma Behice
dc.contributor.author Cinemre, Hakan
dc.contributor.author Abdullah Tuten
dc.contributor.author M. Aytac Yuksel
dc.contributor.author Nevin Yilmaz
dc.contributor.author Bans Kaya
dc.contributor.author Akdemir, Nermin
dc.contributor.author Elif Erdogan
dc.contributor.author Riza Madazli


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