Açık Akademik Arşiv Sistemi

Klotho, vitamin D and homocysteine levels during acute episode and remission periods in schizophrenia patients

Show simple item record

dc.contributor.authors Yazici, E; Pek, TM; Guzel, D; Yazici, AB; Ciner, OA; Erol, A;
dc.date.accessioned 2020-02-27T08:29:08Z
dc.date.available 2020-02-27T08:29:08Z
dc.date.issued 2019
dc.identifier.citation Yazici, E; Pek, TM; Guzel, D; Yazici, AB; Ciner, OA; Erol, A; (2019). Klotho, vitamin D and homocysteine levels during acute episode and remission periods in schizophrenia patients. NORDIC JOURNAL OF PSYCHIATRY, 73, 184-178
dc.identifier.issn 0803-9488
dc.identifier.uri https://doi.org/10.1080/08039488.2019.1582697
dc.identifier.uri https://hdl.handle.net/20.500.12619/66116
dc.description.abstract Aim: Neurodegenerative processes are effective in schizophrenia. However, the underlying causes of the symptoms and associated factors have not yet been fully elucidated. Recent research has focused on the relationship between neurodegeneration and vitamin D, Klotho and homocysteine levels. In this study, we aimed to investigate this relationship in schizophrenia.Method: This study included 30 schizophrenic inpatients, 30 schizophrenic outpatients in remission and 28 healthy volunteers as the control group. The psychiatric diagnoses of our patients were evaluated according to DSM-IV criteria. The Positive and Negative Syndrome Scale (PANSS), the Global Assessment of Functioning (GAF) scale and the Clinical Global Impression (CGI) scale were used for clinical measurements. Serum Klotho, homocysteine, vitamin D, vitamin B12 and folic acid levels were analyzed using ELISA and compared with clinical properties.Results: The PANSS scores and CGI scores were higher in schizophrenic inpatients than outpatients, and the GAF scores were lower (p<0.05). Three groups were compared for Klotho, homocysteine and vitamin D serum levels; Klotho levels were elevated but the difference was not statistically significant (p>0.05). However, vitamin B12, folic acid and homocysteine levels were higher in schizophrenic patients than the control group (p<0.05).Conclusions: Higher levels of homocysteine with concomitant higher levels of vitamin B12 and folic acid suggest a relationship of this pathway with schizophrenia. Differences in Klotho levels were elevated but it was not significant. Replication studies to investigate probable associations with larger samples are needed.
dc.language English
dc.publisher TAYLOR & FRANCIS LTD
dc.subject Psychiatry
dc.title Klotho, vitamin D and homocysteine levels during acute episode and remission periods in schizophrenia patients
dc.type Article
dc.identifier.volume 73
dc.identifier.startpage 178
dc.identifier.endpage 184
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü
dc.contributor.saüauthor Yazıcı, Esra
dc.contributor.saüauthor Güzel, Derya
dc.contributor.saüauthor Yazıcı, Ahmet Bülent
dc.contributor.saüauthor Erol, Atila
dc.relation.journal NORDIC JOURNAL OF PSYCHIATRY
dc.identifier.wos WOS:000465347800003
dc.identifier.doi 10.1080/08039488.2019.1582697
dc.identifier.eissn 1502-4725
dc.contributor.author Yazıcı, Esra
dc.contributor.author Tugba Mutu Pek
dc.contributor.author Güzel, Derya
dc.contributor.author Yazıcı, Ahmet Bülent
dc.contributor.author Ozlem Akcay Ciner
dc.contributor.author Erol, Atila


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record