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Effect of Centrifuge Temperature on Routine Coagulation Tests

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dc.contributor.authors Yazar, H; Ozdemir, F; Kose, E;
dc.date.accessioned 2020-02-27T08:27:02Z
dc.date.available 2020-02-27T08:27:02Z
dc.date.issued 2018
dc.identifier.citation Yazar, H; Ozdemir, F; Kose, E; (2018). Effect of Centrifuge Temperature on Routine Coagulation Tests. ACTA HAEMATOLOGICA, 139, 163-158
dc.identifier.issn 0001-5792
dc.identifier.uri https://doi.org/10.1159/000486271
dc.identifier.uri https://hdl.handle.net/20.500.12619/65913
dc.description.abstract Background: This study investigated the effects of cooled and standard centrifuges on the results of coagulation tests to examine the effects of centrifugation temperature. Methods: Equal-volume blood samples from each patient were collected at the same time intervals and subjected to standard (25 degrees C) and cooled centrifugation (2-4 degrees C). Subsequently, the prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer values were determined in runs with the same lot numbers in the same coagulation device using the Dia-PT R (PT and INR), Dia-PTT-liquid (aPTT), Dia-FIB (fibrinogen), and Dia-D-dimer kits, respectively. Results: The study enrolled 771 participants. The PT was significantly (p < 0.018) higher in participants on anticoagulant therapy. The respective median values of the test parameters determined using the standard and cooled centrifuges were as follows: PT 10.30 versus 10.50 s; PT (INR) 1.04 versus 1.09 s; APTT 28.90 versus 29.40 s; fibrinogen 321.5 versus 322.1 mg/dL; and D-dimer 179.5 versus 168.7 mu g FEU/mL. There were significant differences (p < 0.001) in the parameters between the values obtained with the standard and cooled centrifuges. Conclusions: Centrifuge temperature can have a significant effect on the results of coagulation tests. However, broad and specific disease-based studies are needed. (C) 2018 S. Karger AG, Basel
dc.language English
dc.publisher KARGER
dc.subject Hematology
dc.title Effect of Centrifuge Temperature on Routine Coagulation Tests
dc.type Article
dc.identifier.volume 139
dc.identifier.startpage 158
dc.identifier.endpage 163
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü
dc.contributor.saüauthor Yazar, Hayrullah
dc.contributor.saüauthor Köse, Elif
dc.relation.journal ACTA HAEMATOLOGICA
dc.identifier.wos WOS:000431328300003
dc.identifier.doi 10.1159/000486271
dc.identifier.eissn 1421-9662
dc.contributor.author Yazar, Hayrullah
dc.contributor.author Fatma Ozdemir
dc.contributor.author Köse, Elif


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