Açık Akademik Arşiv Sistemi

Is Change in Hemoglobin Level a Predictive Biomarker of Tyrosine Kinase Efficacy in Metastatic Renal Cell Carcinoma? A Turkish Oncology Group Study

Is Change in Hemoglobin Level a Predictive Biomarker of Tyrosine Kinase Efficacy in Metastatic Renal Cell Carcinoma? A Turkish Oncology Group Study

Bilir, Cemil; Ibrahim Yildiz; Ahmet Bilici; Mahmut Ucar; Veli Berk; Yasar Yildiz; Ozan Yazici; Goksen Inanc Imamoglu; Nuri Karadurmus; Kezban Nur Pilanci; Erkan Arpaci; Ozgur Tanriverdi; Ebru Karci; Suleyman Temiz; Erdinc Nayir; Esin Oktay; Pinar Dal; Ibrahim Petekkaya; Varım, Ceyhun; Cinemre, Hakan
URI: https://doi.org/10.1080/07357907.2017.1292518
https://hdl.handle.net/20.500.12619/65884
Date: 2017

Abstract:

Background: There are insufficient predictive markers for renal cell carcinoma (RCC). Methods: A total of 308 metastatic RCC patients were analyzed retrospectively. Results: The increased hemoglobin (Hb) group had significantly higher progression-free survival and overall survival (OS) compared with the decreased Hb group at 11.5 versus 6.35months (p < .001) and 21.0 versus 11.36months (p < .001) respectively. The 1- and 3-year OS rates were higher in the Hb increased group, i.e., 84% versus 64% and 52% versus 35% respectively. Conclusions: The present study showed that increased Hb levels after tyrosine kinase inhibitor therapy could be a predictive marker of RCC.

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