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Midkine Levels and its Relationship with Atherosclerotic Risk Factors in Essential Hypertensive Patients

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dc.contributor.authors Guzel, S; Cinemre, FBS; Guzel, EC; Kucukyalcin, V; Kiziler, AR; Cavusoglu, C; Gulyasar, T; Cinemre, H; Aydemir, B;
dc.date.accessioned 2020-02-27T07:21:36Z
dc.date.available 2020-02-27T07:21:36Z
dc.date.issued 2018
dc.identifier.citation Guzel, S; Cinemre, FBS; Guzel, EC; Kucukyalcin, V; Kiziler, AR; Cavusoglu, C; Gulyasar, T; Cinemre, H; Aydemir, B; (2018). Midkine Levels and its Relationship with Atherosclerotic Risk Factors in Essential Hypertensive Patients. NIGERIAN JOURNAL OF CLINICAL PRACTICE, 21, 900-894
dc.identifier.issn 1119-3077
dc.identifier.uri https://doi.org/10.4103/njcp.njcp_309_17
dc.identifier.uri https://hdl.handle.net/20.500.12619/65567
dc.description.abstract Background and Objectives: Hypertension (HT) is one of the risk factors associated with atherosclerosis. Midkine (MK) plays a role as a growth factor in various biologic and pathologic events. In some reports, MK expression has been shown to be linked with vascular smooth muscle proliferation and neo-angiogenesis in atherosclerotic vessels. The aim was to research relationship of MK serum levels with some atherosclerotic risk factors in hypertensive patients. Methodology: This study examined 60 patients with essential HT and 30 healthy controls. Serum biochemistry, including lipid profile, MK, Vitamin B 12, C-reactive protein, zinc and copper levels were obtained. Results: MK levels of the HT patients were significantly higher than the control group (24.8 +/- 6.8 ng/mL vs. 18.39 +/- 5.6 ng/mL, respectively, P < 0.01). Lipid profile parameters such as total cholesterol, triglyceride, low-density lipoprotein (LDL) were also significantly higher in HT patients (P < 0.021, P < 0.01, and P < 0.01, respectively). Zinc levels were 179.13 +/- 34.06 mu g/dL and 172.55 +/- 45.47 mu g/dL in the HT and control group, respectively. Serum MK levels were positively correlated with diastolic (r = 0.288, P < 0.05) and systolic blood pressures (r = 0.390, P < 0.002), and also with serum total cholesterol (r = 0.406, P < 0.002) and LDL cholesterol (r = 0.318, P < 0.015) levels. Furthermore MK was also negatively correlated with zinc and Vitamin B 12 levels (r = -0.298, P < 0.023, r = -0.334, P < 0.027, respectively). Conclusion: This study has demonstrated an important association between increased serum MK levels and risk factors of atherosclerosis such as HT, increased total and LDL cholesterol.
dc.language English
dc.publisher WOLTERS KLUWER MEDKNOW PUBLICATIONS
dc.subject General & Internal Medicine
dc.title Midkine Levels and its Relationship with Atherosclerotic Risk Factors in Essential Hypertensive Patients
dc.type Article
dc.identifier.volume 21
dc.identifier.startpage 894
dc.identifier.endpage 900
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü
dc.contributor.saüauthor Cinemre, Fatma Behice
dc.contributor.saüauthor Cinemre, Hakan
dc.contributor.saüauthor Cinemre, Hakan
dc.contributor.saüauthor Aydemir, Birsen
dc.contributor.saüauthor Aydemir, Birsen
dc.relation.journal NIGERIAN JOURNAL OF CLINICAL PRACTICE
dc.identifier.wos WOS:000439047000013
dc.identifier.doi 10.4103/njcp.njcp_309_17
dc.contributor.author S. Guzel
dc.contributor.author F. B. S. Cinemre
dc.contributor.author Cinemre, Fatma Behice
dc.contributor.author E. C. Guzel
dc.contributor.author V. Kucukyalcin
dc.contributor.author A. R. Kiziler
dc.contributor.author C. Cavusoglu
dc.contributor.author T. Gulyasar
dc.contributor.author Cinemre, Hakan
dc.contributor.author Cinemre, Hakan
dc.contributor.author Aydemir, Birsen
dc.contributor.author Aydemir, Birsen


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