Açık Akademik Arşiv Sistemi

Relationship of PCNA, C-erbB2 and CD44s expression with tumor grade and stage in urothelial carcinomas of the bladder

Show simple item record

dc.contributor.authors Yildirim, A; Kosem, M; Sayar, I; Gelincik, I; Yavuz, A; Bozkurt, A; Erkorkmaz, U; Bayram, I
dc.date.accessioned 2020-02-27T07:17:58Z
dc.date.available 2020-02-27T07:17:58Z
dc.date.issued 2014
dc.identifier.citation Yildirim, A; Kosem, M; Sayar, I; Gelincik, I; Yavuz, A; Bozkurt, A; Erkorkmaz, U; Bayram, I (2014). Relationship of PCNA, C-erbB2 and CD44s expression with tumor grade and stage in urothelial carcinomas of the bladder. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 7, 1523-1516
dc.identifier.issn 1940-5901
dc.identifier.uri https://hdl.handle.net/20.500.12619/65314
dc.description.abstract In the present study, the intention was to reveal the relationship of histological grade and stage with c-erbB2, CD44s, and PCNA immunoreactivity in bladder urothelial carcinomas (UC). In our study, we evaluated 46 items of transurethral resection material of patients submitted by YYU Faculty of Medicine, Main Department of Pathology, with a mass revealed in their bladder after clinical and radiological studies at our laboratories and who were diagnosed with urothelial carcinomas. PCNA, c-erbB2, and CD44s were applied in an immunohistochemical manner comprised from nine low-malignant potential papillary urothelial neoplasia, 23 low-grade papillary urothelial carcinoma, and 14 high-grade papillary urothelial carcinoma. Immunostaining was scored according to the percentage of positive cells. The immunohistochemical study demonstrated that the c-erbB2 and PCNA staining ratio increased when an increase occurred in stage and grade. The CD44s staining ratio decreased. C-erbB2, PCNA, and CD44s appear to be a useful marker in the assessment of the prognosis and treatment options in urothelial carcinomas.
dc.language English
dc.publisher E-CENTURY PUBLISHING CORP
dc.subject Urothelial carcinomas; PCNA; CD44; C-erbB2; immunohistochemical study
dc.title Relationship of PCNA, C-erbB2 and CD44s expression with tumor grade and stage in urothelial carcinomas of the bladder
dc.type Article
dc.identifier.volume 7
dc.identifier.startpage 1516
dc.identifier.endpage 1523
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Cerrahi Tıp Bilimleri Bölümü
dc.contributor.saüauthor Kösem, Mustafa
dc.contributor.saüauthor Erkorkmaz, Ünal
dc.relation.journal INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
dc.identifier.wos WOS:000341255900004
dc.contributor.author Yıldırım A
dc.contributor.author Kösem, Mustafa
dc.contributor.author Ilyas Sayar
dc.contributor.author Ibrahim Gelincik
dc.contributor.author Alparslan Yavuz
dc.contributor.author Aliseydi Bozkurt
dc.contributor.author Erkorkmaz, Ünal
dc.contributor.author Irfan Bayram


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record