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Effect of Silybum marianum on acute hepatic damage caused by carbon tetrachloride in rats

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dc.contributor.authors Ozturk, M; Akdogan, M; Keskin, I; Kisioglu, AN; Oztas, S; Yildiz, K;
dc.date.accessioned 2020-02-27T07:17:31Z
dc.date.available 2020-02-27T07:17:31Z
dc.date.issued 2012
dc.identifier.citation Ozturk, M; Akdogan, M; Keskin, I; Kisioglu, AN; Oztas, S; Yildiz, K; (2012). Effect of Silybum marianum on acute hepatic damage caused by carbon tetrachloride in rats. BIOMEDICAL RESEARCH-INDIA, 23, 274-268
dc.identifier.issn 0970-938X
dc.identifier.uri https://hdl.handle.net/20.500.12619/65268
dc.identifier.uri https://doi.org/000306060300021
dc.description.abstract The study was designed to test the efficiency of of Silybum marianum in different doses to treat carbon tetrachloride (CCl4) induced liver damage. Thirty-five Wistar albino rats were divided randomly into five groups as follows: Control Group: 4 ml saline; CCl4 Group: 4 ml saline plus 2 ml/kg CCl4; 2.5% Infusion Group: 2 ml/kg CCl4 plus 2.5% infusion of Silybum marianum; 5% Infusion Group: 2 ml/kg CCl4 plus 5% infusion of Silybum marianum; 10% Infusion Group: 2 ml/kg CCl4 plus 10% infusion of Silybum marianum. Infusions were given once a day for 5 consequtive days. CCl4 was administered intraperitoneally (2 ml/kg) on days 2 and 3. At the end of the 5th day, animals sacrificed and their bloods were drawn for biochemical tests and liver samples were taken for histopathologic investigation. CCl4 caused to incease in glucose and to decrease in albumin, total cholesterol and trigliceride levels. Silybum Marianum treatment improved these changes. All liver function tests were elevated by of CCl4 administration and than reduced, by Silybum Marianum treatment. CCl4 caused to hepatocyte degeneration, central ven dilatation, congestion, and to increase in the number of Kuppfer cells and histopathological injury scores. Treatment with Silybum marianum infusion showed slightly preventive effect on CCl4 induced liver damage by biochemically and histologically.
dc.language English
dc.publisher SCIENTIFIC PUBLISHERS INDIA
dc.subject Research & Experimental Medicine
dc.title Effect of Silybum marianum on acute hepatic damage caused by carbon tetrachloride in rats
dc.type Article
dc.identifier.volume 23
dc.identifier.startpage 268
dc.identifier.endpage 274
dc.contributor.department Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Matematik Bölümü
dc.contributor.saüauthor Öztürk, Mahpeyker
dc.contributor.saüauthor Akdoğan, Mehmet
dc.contributor.saüauthor Yıldız, Kenan
dc.relation.journal BIOMEDICAL RESEARCH-INDIA
dc.identifier.wos WOS:000306060300021
dc.contributor.author Öztürk, Mahpeyker
dc.contributor.author Akdoğan, Mehmet
dc.contributor.author I. Keskin
dc.contributor.author A. N. Kisioglu
dc.contributor.author S. Oztas
dc.contributor.author Yıldız, Kenan


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