Relationships between hypoxia induced factor-1 alpha and F-18-FDG PET/CT parameters in colorectal cancer

Abstract

Conclusion: Although the presence of a positive correlation between tumour SUVmax and %TmNcr shows that there are hypoxic cells in cancer tissue with high FDG uptake, the relationship between the presence of HIF-1 alpha and enhanced glucose metabolism and pathological prognostic factors of tumour was not shown. Strong nuclear immunohistochemical staining in tumour cells adjacent to invasive border and inflammatory cells leads us to believe that HIF-1 alpha plays a role in the invasion area of tumour microenvironment. (C) 2019 Published by Elsevier Espana, S.L.U. on behalf of Sociedad Espanola de Medicina Nuclear e Imagen Molecular.