Synthesis of carbazole bearing pyridopyrimidine-substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity

Arleta Rifati-Nixha; Arslan, Mustafa; Nahit Gencer; Kubra Cikrikici; Basak Gokce; Oktay Arslan

dc.contributor.authors	Rifati-Nixha, A; Arslan, M; Gencer, N; Cikrikici, K; Gokce, B; Arslan, O;
dc.date.accessioned	2020-02-24T14:22:05Z
dc.date.available	2020-02-24T14:22:05Z
dc.date.issued	2019
dc.identifier.citation	Rifati-Nixha, A; Arslan, M; Gencer, N; Cikrikici, K; Gokce, B; Arslan, O; (2019). Synthesis of carbazole bearing pyridopyrimidine-substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 33, -
dc.identifier.issn	1095-6670
dc.identifier.uri	https://doi.org/10.1002/jbt.22306
dc.identifier.uri	https://hdl.handle.net/20.500.12619/45314
dc.description.abstract	The synthesis of carbazole containing pyridopyrimidine-substituted sulfonamide derivatives (3a-i) and their inhibitory effects on human carbonic anhydrase (hCA) I and II were studied. Spectral data and elemental analysis confirmed the structures of the compounds synthesized. The results show that all the synthesized compounds inhibited the CA I and II activities. Among them, 3a was found to be the most active (K-i: 14 mu M) for hCA I and 3f (K-i: 126 mu M) for hCA II.
dc.language	English
dc.publisher	WILEY
dc.subject	Toxicology
dc.title	Synthesis of carbazole bearing pyridopyrimidine-substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity
dc.type	Article
dc.identifier.volume	33
dc.contributor.department	Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü
dc.contributor.saüauthor	Arslan, Mustafa
dc.relation.journal	JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
dc.identifier.wos	WOS:000487281700004
dc.identifier.doi	10.1002/jbt.22306
dc.identifier.eissn	1099-0461
dc.contributor.author	Arleta Rifati-Nixha
dc.contributor.author	Arslan, Mustafa
dc.contributor.author	Nahit Gencer
dc.contributor.author	Kubra Cikrikici
dc.contributor.author	Basak Gokce
dc.contributor.author	Oktay Arslan