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Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials

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dc.contributor.authors Bilgicli, HG; Kestane, A; Taslimi, P; Karabay, O; Bytyqi-Damoni, A; Zengin, M; Gulcin, I;
dc.date.accessioned 2020-02-24T14:21:45Z
dc.date.available 2020-02-24T14:21:45Z
dc.date.issued 2019
dc.identifier.citation Bilgicli, HG; Kestane, A; Taslimi, P; Karabay, O; Bytyqi-Damoni, A; Zengin, M; Gulcin, I; (2019). Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials. BIOORGANIC CHEMISTRY, 88, -
dc.identifier.issn 0045-2068
dc.identifier.uri https://doi.org/10.1016/j.bioorg.2019.102931
dc.identifier.uri https://hdl.handle.net/20.500.12619/45299
dc.description.abstract Five oxypropanol amine derivatives that four of them are novel have been synthesized with high yields and practical methods. in vitro antibacterial susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus strains to synthesized substances were evaluated with agar well-diffusion method by comparison with commercially available drugs. Most of the bacteria were multidrug resistant. It was concluded that these compounds are much more effective than reference drugs. These eugenol bearing oxypropanolamine derivatives were also effective inhibitors against alpha-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) enzymes with K-i values in the range of 0.80 +/- 0.24-3.52 +/- 1.01 mu M for hCA I, 1.08 +/- 0.15-3.64 +/- 0.92 mu M for hCA II, 5.18 +/- 0.84-12.46 +/- 2.08 mu M for alpha-glycosidase, and 11.33 +/- 2.83-32.81 +/- 9.73 mu M for AChE, respectively.
dc.language English
dc.publisher ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.subject Chemistry
dc.title Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials
dc.type Article
dc.identifier.volume 88
dc.contributor.department Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü
dc.contributor.saüauthor Genç Bilgiçli, Hayriye
dc.contributor.saüauthor Karabay, Oğuz
dc.contributor.saüauthor Zengin, Mustafa
dc.relation.journal BIOORGANIC CHEMISTRY
dc.identifier.wos WOS:000475378400025
dc.identifier.doi 10.1016/j.bioorg.2019.102931
dc.identifier.eissn 1090-2120
dc.contributor.author Genç Bilgiçli, Hayriye
dc.contributor.author Ali Kestane
dc.contributor.author Parham Taslimi
dc.contributor.author Karabay, Oğuz
dc.contributor.author Arlinda Bytyqi-Damoni
dc.contributor.author Zengin, Mustafa
dc.contributor.author Ilhami Gulcin


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