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Novel thymol bearing oxypropanolamine derivatives as potent some metabolic enzyme inhibitors - Their antidiabetic, anticholinergic and antibacterial potentials

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dc.contributor.authors Zengin, M; Genc, H; Taslimi, P; Kestane, A; Guclu, E; Ogutlu, A; Karabay, O; Gulcin, I;
dc.date.accessioned 2020-02-24T14:19:58Z
dc.date.available 2020-02-24T14:19:58Z
dc.date.issued 2018
dc.identifier.citation Zengin, M; Genc, H; Taslimi, P; Kestane, A; Guclu, E; Ogutlu, A; Karabay, O; Gulcin, I; (2018). Novel thymol bearing oxypropanolamine derivatives as potent some metabolic enzyme inhibitors - Their antidiabetic, anticholinergic and antibacterial potentials. BIOORGANIC CHEMISTRY, 81, 126-119
dc.identifier.issn 0045-2068
dc.identifier.uri https://doi.org/10.1016/j.bioorg.2018.08.003
dc.identifier.uri https://hdl.handle.net/20.500.12619/45210
dc.description.abstract A series of classical and newly synthesized thymol bearing oxypropanolamine compounds were synthesized and characterized. Their in vitro antibacterial activity on A. baumannii, P. aeruginosa, E. coli and S. aureus strains were investigated with agar well diffusion method. The results were compared with commercially available drug active compounds. As well as 3a, 3b and 3c have the most significant antibacterial effect among all the tested compounds; approximately all of them have more antibacterial activity than the reference drugs. These novel thymol bearing oxypropanolamine derivatives were effective inhibitors of the a-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase enzymes (AChE) with K-f values in the range of 463.85-851.05 mu M for alpha-glycosidase, 1.11-17.34 mu M for hCA I, 2.97-17.83 mu M for hCA II, and 13.58-31.45 mu M for AChE, respectively.
dc.language English
dc.publisher ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.subject Chemistry
dc.title Novel thymol bearing oxypropanolamine derivatives as potent some metabolic enzyme inhibitors - Their antidiabetic, anticholinergic and antibacterial potentials
dc.type Article
dc.identifier.volume 81
dc.identifier.startpage 119
dc.identifier.endpage 126
dc.contributor.department Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü
dc.contributor.saüauthor Zengin, Mustafa
dc.contributor.saüauthor Genç Bilgiçli, Hayriye
dc.contributor.saüauthor Güçlü, Ertuğrul
dc.contributor.saüauthor Öğütlü, Aziz
dc.contributor.saüauthor Karabay, Oğuz
dc.relation.journal BIOORGANIC CHEMISTRY
dc.identifier.wos WOS:000449428400013
dc.identifier.doi 10.1016/j.bioorg.2018.08.003
dc.identifier.eissn 1090-2120
dc.contributor.author Zengin, Mustafa
dc.contributor.author Genç Bilgiçli, Hayriye
dc.contributor.author Parham Taslimi
dc.contributor.author Ali Kestane
dc.contributor.author Güçlü, Ertuğrul
dc.contributor.author Öğütlü, Aziz
dc.contributor.author Karabay, Oğuz
dc.contributor.author Ilhami Gulcin


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