Biotransformation of androst-4-ene-3,17-dione by some fungi

Abstract

The incubations of androst-4-ene-3,17-dione with Aspergillus candidus MRC 200634, Aspergillus tamarii MRC 72400, Aspergillus wentii MRC 200316 and Mucor hiemalis MRC 70325 for 5 days are reported. A. candidus MRC 200634 mainly hydroxylated androst-4-ene-3,17-dione at C-11 alpha, C-15 alpha and C-15 beta whilst A. wentii MRC 200316 hydroxylated it mainly at C-6 beta. A. tamarii MRC 72400 showed predominately a Baeyer-Villiger monooxygenase activity. M. hiemalis MRC 70325 hydroxylated the substrate at C-14 alpha and reduced most of it at C-17.