Discovery of Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors: 2-Aminoindan beta-Lactam Derivatives

Genç Bilgiçli, Hayriye; Zengin, Mustafa

dc.contributor.authors	Genc, H; Kalin, R; Koksal, Z; Sadeghian, N; Kocyigit, UM; Zengin, M; Gulcin, I; Ozdemir, H;
dc.date.accessioned	2020-02-24T14:18:26Z
dc.date.available	2020-02-24T14:18:26Z
dc.date.issued	2016
dc.identifier.citation	Genc, H; Kalin, R; Koksal, Z; Sadeghian, N; Kocyigit, UM; Zengin, M; Gulcin, I; Ozdemir, H; (2016). Discovery of Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors: 2-Aminoindan beta-Lactam Derivatives. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17, -
dc.identifier.issn	1422-0067
dc.identifier.uri	https://doi.org/10.3390/ijms17101736
dc.identifier.uri	https://hdl.handle.net/20.500.12619/45122
dc.description.abstract	beta-Lactams are pharmacologically important compounds because of their various biological uses, including antibiotic and so on. beta-Lactams were synthesized from benzylidene-inden derivatives and acetoxyacetyl chloride. The inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and acetylcholinesterase (AChE). The results reveal that beta-lactams are inhibitors of hCA I, II and AChE. The Ki values of beta-lactams (2a-k) were 0.44-6.29 nM against hCA I, 0.93-8.34 nM against hCA II, and 0.25-1.13 nM against AChE. Our findings indicate that beta-lactams (2a-k) inhibit both carbonic anhydrases (CA) isoenzymes and AChE at low nanomolar concentrations.
dc.language	English
dc.publisher	MDPI
dc.subject	Chemistry
dc.title	Discovery of Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors: 2-Aminoindan beta-Lactam Derivatives
dc.type	Article
dc.identifier.volume	17
dc.contributor.department	Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü
dc.contributor.saüauthor	Genç Bilgiçli, Hayriye
dc.contributor.saüauthor	Zengin, Mustafa
dc.relation.journal	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
dc.identifier.wos	WOS:000387768300031
dc.identifier.doi	10.3390/ijms17101736
dc.contributor.author	Genç Bilgiçli, Hayriye
dc.contributor.author	Zengin, Mustafa