Investigation on Effects of Schiff Base Complex to Hydroxyapatite Bioceramics

Abstract

The aim of this study was to evaluate the effects of Schiff base metal complex on the bio-compatible hydroxyapatite (HAp) ceramics. The reason for that was to produce, as the final product, the HAp in powder form, with extraordinary features like analgesic, antibacterial properties. This effect was provided by doping HAp powder with some Schiff base complexes during the powder extraction process. Schiff base complex used in the study was synthesized by condensation of primary amines with carbonyl compounds. The chemical structures of the synthesized compounds were confirmed by means of infrared (IR) spectroscopy and elemental analysis. Characterizations of the extracted HAp powders were carried out by using scanning electron microscopy for surface analysis and EDS analysis, X-ray diffraction for phase determination and grain size distribution. The bactericide effects of Zn SAE-added pure HAp were tested on E.Coli bacteria for the content range of 0-7 wt.% of Zn-SAE. Consequently, bacterial activity of the calcium phosphate resulting powders was evolved by adding the Zn SAE Schiff base complex.