In vitro inhibition of polyphenol oxidase by some new diarylureas

Genç Bilgiçli, Hayriye; Zengin, Mustafa

dc.contributor.authors	Demir, D; Gencer, N; Arslan, O; Genc, H; Zengin, M;
dc.date.accessioned	2020-02-24T14:15:18Z
dc.date.available	2020-02-24T14:15:18Z
dc.date.issued	2012
dc.identifier.citation	Demir, D; Gencer, N; Arslan, O; Genc, H; Zengin, M; (2012). In vitro inhibition of polyphenol oxidase by some new diarylureas. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 27, 131-125
dc.identifier.issn	1475-6366
dc.identifier.uri	https://doi.org/10.3109/14756366.2011.580743
dc.identifier.uri	https://hdl.handle.net/20.500.12619/44865
dc.description.abstract	A new series of N,N'-diarylureas (1-9) was synthesized. These compounds were investigated as inhibitors of polyphenol oxidase (PPO) which had been purified from banana by an affinity gel comprised of Sepharose 4B-L-tyrosine-p-amino benzoic acid. K-i values for (1), (2), (3), (5), (6), (7) and (8) were determined as 0.285, 17.97, 0.187, 0.108, 0.063, 0.044 and 0.047 mM, respectively. Thus (2) was by far the most effective inhibitor. Interestingly, (4) and (9) behaved as an activator of PPO in this study.
dc.language	English
dc.publisher	INFORMA HEALTHCARE
dc.subject	Pharmacology & Pharmacy
dc.title	In vitro inhibition of polyphenol oxidase by some new diarylureas
dc.type	Article
dc.identifier.volume	27
dc.identifier.startpage	125
dc.identifier.endpage	131
dc.contributor.department	Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü
dc.contributor.saüauthor	Genç Bilgiçli, Hayriye
dc.contributor.saüauthor	Zengin, Mustafa
dc.relation.journal	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
dc.identifier.wos	WOS:000298748800019
dc.identifier.doi	10.3109/14756366.2011.580743
dc.contributor.author	Genç Bilgiçli, Hayriye
dc.contributor.author	Zengin, Mustafa