Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors

Sönmez, Fatih; Sevmezler, Sedat; Ceylan, Mücahit; Küçükislamoğlu, Mustafa

dc.contributor.authors	Sonmez, F; Sevmezler, S; Atahan, A; Ceylan, M; Demir, D; Gencer, N; Arslan, O; Kucukislamoglu, M
dc.date.accessioned	2020-02-24T14:14:51Z
dc.date.available	2020-02-24T14:14:51Z
dc.date.issued	2011
dc.identifier.citation	Sonmez, F; Sevmezler, S; Atahan, A; Ceylan, M; Demir, D; Gencer, N; Arslan, O; Kucukislamoglu, M (2011). Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21, 7482-7479
dc.identifier.issn	0960-894X
dc.identifier.uri	https://doi.org/10.1016/j.bmcl.2011.09.130
dc.identifier.uri	https://hdl.handle.net/20.500.12619/44810
dc.description.abstract	A newly series of 4-(phenylurenyl) chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-L-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity. (C) 2011 Elsevier Ltd. All rights reserved.
dc.language	English
dc.publisher	PERGAMON-ELSEVIER SCIENCE LTD
dc.title	Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors
dc.type	Article
dc.identifier.volume	21
dc.identifier.startpage	7479
dc.identifier.endpage	7482
dc.contributor.department	Sakarya Uygulamalı Bilimler Üniversitesi/Pamukova Meslek Yüksekokulu/Gıda İşleme Bölümü
dc.contributor.saüauthor	Sönmez, Fatih
dc.contributor.saüauthor	Sevmezler, Sedat
dc.contributor.saüauthor	Ceylan, Mücahit
dc.contributor.saüauthor	Küçükislamoğlu, Mustafa
dc.relation.journal	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
dc.identifier.wos	WOS:000297150600048
dc.identifier.doi	10.1016/j.bmcl.2011.09.130
dc.identifier.eissn	1464-3405
dc.contributor.author	Sönmez, Fatih
dc.contributor.author	Sevmezler, Sedat
dc.contributor.author	Ceylan, Mücahit
dc.contributor.author	Küçükislamoğlu, Mustafa