BIOTRANSFORMATION OF SOME STEROIDS BY Aspergillus terreus MRC 200365

Abstract

The biotransformations of testosterone, epiandrosterone, progesterone and pregnenolone by Aspergillus terreus MRC 200365 for five days were described. The biotransformation of testosterone afforded testolactone. The biotransformation of epiandrosterone afforded 3 beta-hydroxy-17a-oxa-D-homo-5 alpha-androstan-17-one. The biotransformation of progesterone afforded androst-4-ene-3,17-dione and testolactone. The biotransformation of pregnenolone afforded 3 beta-hydroxy-17a-oxa-D-homoandrost-5-en-17-one and testolactone.