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Regression of the Carotid Intima Media Thickness by Propylthiouracil Therapy in Graves' Hyperthyroidism

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dc.contributor.authors Bilir, C; Gokosmanoglu, F; Caliskan, M; Cinemre, H; Akdemir, R;
dc.date.accessioned 2020-01-15T06:44:33Z
dc.date.available 2020-01-15T06:44:33Z
dc.date.issued 2012
dc.identifier.citation Bilir, C; Gokosmanoglu, F; Caliskan, M; Cinemre, H; Akdemir, R; (2012). Regression of the Carotid Intima Media Thickness by Propylthiouracil Therapy in Graves' Hyperthyroidism. AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 343, 276-273
dc.identifier.issn 0002-9629
dc.identifier.uri https://hdl.handle.net/20.500.12619/3909
dc.identifier.uri https://doi.org/10.1097/MAJ.0b013e31822a8284
dc.description.abstract Introduction: One of the cardiovascular effects of hyperthyroidism is increased carotid intima media thickness (CIMT). The aim of this study is to investigate the CIMT in patients with Graves' hyperthyroidism and the effect of propylthiouracil (PTU) therapy on CIMT. Method: Twenty-six patients with Graves' hyperthyroidism and 33 healthy controls were included in the study. CIMT was measured at the right and left external carotid arteries in every patient in both groups. CIMT was measured before and after the PTU therapy in patients with Graves' hyperthyroidism. Results: There was a significant difference in CIMT between the group of Graves' hyperthyroid patients and the control group (0.72 versus 0.55 mm, P < 0.0001) at baseline. Twenty-five of 26 patients with Graves' disease were followed up for 18 months prospectively. Euthyroidism has been achieved in 21 patients. After 18 months of treatment, CIMT decreased significantly compared with the baseline values [0.84 (0.54-1.3) to 0.72 (0.50-1.2), change 0.12 mm, P < 0.001]. Conclusion: Graves' hyperthyroidism is associated with atherosclerosis as assessed by CIMT. Treatment of Graves' hyperthyroidism with PTU decreases the CIMT.
dc.language English
dc.publisher ELSEVIER SCIENCE INC
dc.subject General & Internal Medicine
dc.title Regression of the Carotid Intima Media Thickness by Propylthiouracil Therapy in Graves' Hyperthyroidism
dc.type Article
dc.identifier.volume 343
dc.identifier.startpage 273
dc.identifier.endpage 276
dc.contributor.department Sakarya Üniversitesi/Siyasal Bilgiler Fakültesi/İktisat Bölümü
dc.contributor.saüauthor Çalışkan, Mustafa
dc.contributor.saüauthor Cinemre, Hakan
dc.contributor.saüauthor Akdemir, Ramazan
dc.relation.journal AMERICAN JOURNAL OF THE MEDICAL SCIENCES
dc.identifier.wos WOS:000302158400002
dc.identifier.doi 10.1097/MAJ.0b013e31822a8284
dc.identifier.eissn 1538-2990
dc.contributor.author Çalışkan, Mustafa
dc.contributor.author Cinemre, Hakan
dc.contributor.author Akdemir, Ramazan


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