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Liver involvement in patients with brucellosis: results of the Marmara study

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dc.contributor.authors Ozturk-Engin, D; Erdem, H; Gencer, S; Kaya, S; Baran, AI; Batirel, A; Tekin, R; Celen, MK; Denk, A; Guler, S; Ulug, M; Turan, H; Pekok, AU; Mermut, G; Kaya, S; Tasbakan, M; Tulek, N; Cag, Y; Inan, A; Yalci, A; Ataman-Hatipoglu, C; Gonen, I;
dc.date.accessioned 2020-01-20T11:42:13Z
dc.date.available 2020-01-20T11:42:13Z
dc.date.issued 2014
dc.identifier.citation Ozturk-Engin, D; Erdem, H; Gencer, S; Kaya, S; Baran, AI; Batirel, A; Tekin, R; Celen, MK; Denk, A; Guler, S; Ulug, M; Turan, H; Pekok, AU; Mermut, G; Kaya, S; Tasbakan, M; Tulek, N; Cag, Y; Inan, A; Yalci, A; Ataman-Hatipoglu, C; Gonen, I; (2014). Liver involvement in patients with brucellosis: results of the Marmara study. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 33, 1262-1253
dc.identifier.issn 0934-9723
dc.identifier.uri https://hdl.handle.net/20.500.12619/33386
dc.description.abstract Brucellosis is a zoonotic disease that primarily affects the reticuloendothelial system. But, the extent of liver damage in due course of the disease is unclear. This study included 325 brucellosis patients with significant hepatobiliary involvement identified with microbiological analyses from 30 centers between 2000 and 2013. The patients with a parts per thousand yen5 times of the upper limit of normal for aminotransferases, total bilirubin level a parts per thousand yen2 mg/dl or local liver lesions were enrolled. Clinical hepatitis was detected in 284 patients (87.3 %) and cholestasis was detected in 215 (66.1 %) patients. Fatigue (91 %), fever (86 %), sweating (83 %), arthralgia (79 %), and lack of appetite (79 %) were the major symptoms. Laboratory tests showed anemia in 169 (52 %), thrombocytopenia in 117 (36 %), leukopenia in 81 (25 %), pancytopenia in 42 (13 %), and leukocytosis in 20 (6 %) patients. The most commonly used antibiotic combinations were doxycycline plus an aminoglycoside (n = 73), doxycycline plus rifampicin (n = 71), doxycycline plus rifampicin and an aminoglycoside (n = 27). The duration of ALT normalization differed significantly in three treatment groups (p < 0.001). The use of doxycycline and an aminoglycoside in clinical hepatitis showed better results compared to doxycycline and rifampicin or rifampicin, aminoglycoside, doxycycline regimens (p < 0.05). However, the length of hospital stay did not differ significantly between these three combinations (p > 0.05). During the follow-up, treatment failure occurred in four patients (1 %) and relapse was seen in three patients (0.9 %). Mortality was not observed. Hepatobiliary involvement in brucellosis has a benign course with suitable antibiotics and the use of doxycycline and an aminoglycoside regimen seems a better strategy in select patients.
dc.description.uri https://doi.org/10.1007/s10096-014-2064-4
dc.language English
dc.publisher SPRINGER
dc.title Liver involvement in patients with brucellosis: results of the Marmara study
dc.type Article
dc.identifier.volume 33
dc.identifier.startpage 1253
dc.identifier.endpage 1262
dc.contributor.department Sakarya Üniversitesi/İlahiyat Fakültesi/Temel İslam Bilimleri Bölümü
dc.contributor.saüauthor Kaya, Süleyman
dc.contributor.saüauthor Kaya, Süleyman
dc.relation.journal EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
dc.identifier.wos WOS:000336986700024
dc.identifier.doi 10.1007/s10096-014-2064-4
dc.contributor.author D. Ozturk-Engin
dc.contributor.author H. Erdem
dc.contributor.author S. Gencer
dc.contributor.author Kaya, Süleyman
dc.contributor.author A. I. Baran
dc.contributor.author A. Batirel
dc.contributor.author R. Tekin
dc.contributor.author M. K. Celen
dc.contributor.author A. Denk
dc.contributor.author S. Guler
dc.contributor.author M. Ulug
dc.contributor.author H. Turan
dc.contributor.author A. U. Pekok
dc.contributor.author G. Mermut
dc.contributor.author Kaya, Süleyman
dc.contributor.author M. Tasbakan
dc.contributor.author N. Tulek
dc.contributor.author Y. Cag
dc.contributor.author A. Inan
dc.contributor.author A. Yalci
dc.contributor.author C. Ataman-Hatipoglu
dc.contributor.author I. Gonen
dc.contributor.author A. Dogan-Celik


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