Açık Akademik Arşiv Sistemi

Developmental Toxicity of (4S)-2-(4-hydroxy-3-methoxyphenyl)thiazolidine-4-carboxylic acid in Zebrafish (Danio rerio)

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dc.contributor.authors Akbulut, C; Ozturk, B; Genc, H; Zengin, M; Yon, ND;
dc.date.accessioned 2020-01-20T09:03:56Z
dc.date.available 2020-01-20T09:03:56Z
dc.date.issued 2017
dc.identifier.citation Akbulut, C; Ozturk, B; Genc, H; Zengin, M; Yon, ND; (2017). Developmental Toxicity of (4S)-2-(4-hydroxy-3-methoxyphenyl)thiazolidine-4-carboxylic acid in Zebrafish (Danio rerio). BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY, 60, -
dc.identifier.issn 1516-8913
dc.identifier.uri https://hdl.handle.net/20.500.12619/33332
dc.description.abstract (4S)-2-(4-hydroxy-3-methoxyphenyl)thiazolidine-4-carboxylic acid is new synthesized substance obtained from cysteine and valine. Thiazolidine derivates have important biological responses so scientists work intensively on these compounds in recent years. It is obvious that thiazolidine contained compounds will be used in future in the pharmaceutical industry to treat important diseases. Median lethal concentrations (LC50) for 48 h and 96 h were found as 1.106 +/- 0.052 mM and 0.804 mM +/- 0.102 respectively. According to LC50, exposure doses were determined as control, 0.4 mM, 0.2 mM and 0.1 mM (4S)-2-(4-hydroxy-3-methoxyphenyl)thiazolidine-4-carboxylic acid. Developmental toxicity and apoptotic features on zebrafish development were evaluated in this study. The results of this study indicate that (4S)-2-(4-hydroxy-3-methoxyphenyl)thiazolidine-4-carboxylic acid exposure cause developmental defects like pericardial edema, bent spine, tail malformation, blood accumulation, yolk sac edema but on the other hand concentration-dependent decrease in apoptotic rate. Likewise, concentration-dependent decrease in hatching and increase in mortality of embryos were also detected.
dc.language English
dc.publisher INST TECNOLOGIA PARANA
dc.subject Life Sciences & Biomedicine - Other Topics
dc.title Developmental Toxicity of (4S)-2-(4-hydroxy-3-methoxyphenyl)thiazolidine-4-carboxylic acid in Zebrafish (Danio rerio)
dc.type Article
dc.identifier.volume 60
dc.contributor.department Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü
dc.contributor.saüauthor Akbulut, Cansu
dc.contributor.saüauthor Genç Bilgiçli, Hayriye
dc.contributor.saüauthor Zengin, Mustafa
dc.contributor.saüauthor Yön Ertuğ, Nazan Deniz
dc.relation.journal BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
dc.identifier.wos WOS:000410082400001
dc.identifier.eissn 1678-4324
dc.contributor.author Akbulut, Cansu
dc.contributor.author Burcu Ozturk
dc.contributor.author Genç Bilgiçli, Hayriye
dc.contributor.author Zengin, Mustafa
dc.contributor.author Yön Ertuğ, Nazan Deniz


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