Açık Akademik Arşiv Sistemi

Synthesis, characterization, and determination of genotoxic effect of a novel dimeric 8-hydroxyquinoline Cd(II) SCN complex

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dc.contributor.authors Tunca, H; Berber, AA; Canakci, K; Tuna, M; Yildiz, SZ; Aksoy, H;
dc.date.accessioned 2020-01-20T09:03:55Z
dc.date.available 2020-01-20T09:03:55Z
dc.date.issued 2017
dc.identifier.citation Tunca, H; Berber, AA; Canakci, K; Tuna, M; Yildiz, SZ; Aksoy, H; (2017). Synthesis, characterization, and determination of genotoxic effect of a novel dimeric 8-hydroxyquinoline Cd(II) SCN complex. DRUG AND CHEMICAL TOXICOLOGY, 40, 308-300
dc.identifier.issn 0148-0545
dc.identifier.uri https://hdl.handle.net/20.500.12619/33327
dc.identifier.uri https://doi.org/10.1080/01480545.2016.1223094
dc.description.abstract In this study, a Cd(II) complex was synthesized using 8-hydroxyquinoline and thiocyanate as the ligands and structurally characterized with the combination of FTIR, H-1-NMR, C-13-NMR, UV-vis, and MS spectral data. Then, genotoxic effects of the prepared complex were investigated. Genotoxic properties of the dimeric 8-hydroxyquinolinthiocyanatoCd(II) [Cd-2(8Q)(2)(SCN)(2)] complex synthesized as drug raw material were analyzed in human peripheral blood lymphocytes. Concentrations of 1, 2, 4, 6, and 8g/mL [Cd-2(8Q)(2)(SCN)(2)] were used for 24 and 48 h durations. [Cd-2(8Q)(2)(SCN)(2)] significantly increased chromosomal aberrations (CAs) at 4, 6, and 8g/mL concentrations after a 24-h period and 2 and 4g/mL after a 48-h period. [Cd-2(8Q)(2)(SCN)(2)] significantly decreased the mitotic index (MI) at all concentrations, both at 24 and 48h. Micronuclei frequency (MN) was not affected by [Cd-2(8Q)(2)(SCN)(2)] treatment compared with the control. After application for a 48h period, 6 and 8 mu g/mL concentrations showed toxic effects both in chromosomal abnormality and in micronucleus tests. It also decreased the cytokinesis-block proliferation index (CBPI), but this result was statistically significant only at 6 and 8 mu g/mL concentrations. In the comet assay (single-cell gel electrophoresis (SCGE)), significant increases in comet tail length, tail moment, and tail intensity were observed at all concentrations. [Cd-2(8Q)(2)(SCN)(2)] displays clastogenic effect in the concentrations used in human peripheral lymphocytes at chromosomal abnormality, micronucleus tests, and cytokinesis-block proliferation index parameters. Further studies should be conducted in other test systems to evaluate the complete genotoxic potential of [Cd-2(8Q)(2)(SCN)(2)].
dc.language English
dc.publisher TAYLOR & FRANCIS LTD
dc.subject Toxicology
dc.title Synthesis, characterization, and determination of genotoxic effect of a novel dimeric 8-hydroxyquinoline Cd(II) SCN complex
dc.type Article
dc.identifier.volume 40
dc.identifier.startpage 300
dc.identifier.endpage 308
dc.contributor.department Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü
dc.contributor.saüauthor Tunca, Hatice
dc.contributor.saüauthor Berber, Ahmet Ali
dc.contributor.saüauthor Tuna, Murat
dc.contributor.saüauthor Yıldız, Salih Zeki
dc.contributor.saüauthor Aksoy, Hüseyin
dc.relation.journal DRUG AND CHEMICAL TOXICOLOGY
dc.identifier.wos WOS:000399743000008
dc.identifier.doi 10.1080/01480545.2016.1223094
dc.identifier.eissn 1525-6014
dc.contributor.author Tunca, Hatice
dc.contributor.author Berber, Ahmet Ali
dc.contributor.author Kubra Canakci
dc.contributor.author Tuna, Murat
dc.contributor.author Yıldız, Salih Zeki
dc.contributor.author Aksoy, Hüseyin


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