Histological Changes in Zebrafish (Danio rerio) Ovaries Following Administration of Bisphenol A

Abstract

Bisphenol A (BPA) is one of the most potent endocrine disrupting chemicals and therefore is classified as environmental estrogen. BPA is found in polycarbonate plastics (baby feeding bottles, carboys, etc.) and inside of epoxy coated cans and it is widely used in industry for making plastics harder. The aim of this study is to investigate histopathological changes after exposure of different doses of bisphenol A in zebrafish (Dania rerio) ovaries. The zebrafish are divided into three groups (n=30) according to their different BPA (group I: 3 mg/L BPA; group II: 5 mg/L BPA; group III: control group) concentrations. Histological studies showed severe deterioration of ovarian tissue. The number of the atretic oocytes increased BPA. Structurally distorted and less developed oocytes were also observed. To conclude, the acute doses of BPA slowed down the process of oogenesis in zebrafish.