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Browsing Kimya / Chemistry by Subject "Pharmacology & Pharmacy"

Now showing items 1-19 of 19

Biotransformation of Some Steroids by Aspergillus wentii

Yıldırım, Kudret (WALTER DE GRUYTER GMBH, 2010)

First steroid biotransformations performed by Aspergillus wentii MRC 200316 are reported. Testosterone (1) yields 6 beta-hydroxytestosterone (3) and 14 alpha-hydroxytestosterone (4) while progesterone (2) yields 11 ...
Characterization of polyphenol oxidase from quince (Cydonia oblonga) leaves

Arabacı, Gülnur; Ayse Usluoglu (TAYLOR & FRANCIS LTD, 2010)
Comparative study of electrospray mass spectrometry and first derivative method and validation by HPLC method

Özdemir, Abdil (FOOD & DRUG ADMINSTRATION, 2007)

Three different methods are described for the simultaneous determination of amoxicillin trihydrate (AMX) and potassium klavulanate (KLV) in synthetic mixtures and pharmaceutical tablets. The first method depends on the ...
Comparative study of the continuous wavelet transform, derivative and partial least squares methods applied to the overlapping spectra for the simultaneous quantitative resolution of ascorbic acid and acetylsalicylic acid in effervescent tablets

Özdemir, Abdil (ELSEVIER SCIENCE BV, 2005)

The simultaneous spectrophotometric determination of ascorbic acid (AA) and acetylsalicylic acid (ASA) in effervescent tablets in the presence of the overlapping spectra was accomplished by the continuous wavelet transform ...
Design, synthesis and docking study of novel coumarin ligands as potential selective acetylcholinesterase inhibitors

Sönmez, Fatih; Belma Zengin Kurt; Isil Gazioglu; Livia Basile; Aydan Dag; Valentina Cappello; Tiziana Ginex; Küçükislamoğlu, Mustafa; Salvatore Guccione (TAYLOR & FRANCIS LTD, 2017)

New coumaryl-thiazole derivatives with the acetamide moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and in vitro tested as acetylcholinesterase (AChE) inhibitors. 2-(diethylam ...
Determination of Some Metal Levels in Multivitamin Tablets by ICP-OES after Different Digestion Methods

Merve Timirli Zurnaci; Küçük Tunca, Aysel (COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES, 2017)

The aim of this study is to determine the quantities of Fe, Cu, Mn and Zn, the common trace metals contained in Supradyn and Pharmaton multivitamin tablets used widely by the consumers and compare them with the reference ...
Experimental studies on newly synthesised *TTTBI and computational studies on *CTTBI and* CCTBI

Tutar, Ahmet (PROUS SCIENCE, SA, 2007)
In vitro inhibition of polyphenol oxidase by some new diarylureas

Genç Bilgiçli, Hayriye; Zengin, Mustafa (INFORMA HEALTHCARE, 2012)

A new series of N,N'-diarylureas (1-9) was synthesized. These compounds were investigated as inhibitors of polyphenol oxidase (PPO) which had been purified from banana by an affinity gel comprised of Sepharose 4B-L-tyros ...
Potential of aryl-urea-benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease

Sönmez, Fatih; Küçükislamoğlu, Mustafa (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2015)

New benzofuranylthiazole derivatives containing the aryl urea moiety were synthesized and evaluated in vitro as dual acetylcholinesterase (AChE)-butyrylcholinesterase (BuChE) inhibitors. In addition, the cupric reducing ...
SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors

Salih Okten; Makbule Ekiz; Tutar, Ahmet; Burcu Butun; Umit Muhammet Kocyigit; Gulacti Topcu; Ilhami Gulcin (ASSOC PHARMACEUTICAL TEACHERS INDIA, 2019)

Background: The inhibition of both hydrolysis products of acetylcholine (ACh), Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE), is essential for successful treatment of Alzhemier patients. Objectives: This ...
Synthesis and evaluation of N-heteroarylsubstituted triazolosulfonamides as carbonic anhydrase inhibitors

Ahmet Balci; Arslan, Mustafa; Arleta Rifati Nixha; Cigdem Bilen; Adem Ergun; Nahit Gencer (TAYLOR & FRANCIS LTD, 2015)

A new series of N-heteroarylsubstituted triazolosulfonamide compounds were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and II were evaluated. Compounds (3 a-k) were ...
Synthesis and evaluation of sulfonamide-bearing thiazole as carbonic anhydrase isoforms hCA I and hCA II

Arslan, Mustafa (TAYLOR & FRANCIS LTD, 2016)

Sulfonamide-bearing thiazole compounds were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase I and II were evaluated. Human carbonic anhydrase isoenzymes (hCA-I and hCA-II) were ...
Synthesis and theoretical calculations of carbazole substituted chalcone urea derivatives and studies their polyphenol oxidase enzyme activity

Arslan, Mustafa; Atalay, Yusuf (TAYLOR & FRANCIS LTD, 2013)

Synthesis of carbazole substituted chalcone urea derivatives and their polyphenol oxidase enzyme activity effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana ...
Synthesis of dihydropyrimidinones catalyzed by zirconium phosphate and alumina sulphuric acid under solvent-free conditions

Beşoluk, Şenol; Nebioğlu, Mehmet; Zengin, Mustafa; Arslan, Mustafa; Küçükislamoğlu, Mustafa (PROUS SCIENCE, SA, 2007)
Synthesis, antioxidant activity and SAR study of novel spiro-isatin-based Schiff bases

Sönmez, Fatih; Zuhal Gunesli; Belma Zengin Kurt; Isil Gazioglu; Avcı, Davut; Küçükislamoğlu, Mustafa (SPRINGER, 2019)

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Synthesis, antioxidant and carbonic anhydrase I and II inhibitory activities of novel sulphonamide-substituted coumarylthiazole derivatives

Sönmez, Fatih; Küçükislamoğlu, Mustafa (TAYLOR & FRANCIS LTD, 2016)

New secondary benzenesulphonamide-substituted coumarylthiazole derivatives were synthesized and their inhibitory effects on purified carbonic anhydrase I and II were evaluated using CO2 as a substrate. The result showed ...
Synthesis, biological activity and multiscale molecular modeling studies for coumaryl-carboxamide derivatives as selective carbonic anhydrase IX inhibitors

Belma Zengin Kurt; Sönmez, Fatih; Serdar Durdagi; Busecan Aksoydan; Ramin Ekhteiari Salmas; Andrea Angeli; Küçükislamoğlu, Mustafa; Claudiu T. Supuran (TAYLOR & FRANCIS LTD, 2017)

New coumaryl-carboxamide derivatives with the thiourea moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and their inhibitory activity against the human carbonic anhydrase (hCA) ...
The effect of various metals on polyphenol oxidase and peroxidase activities from goosefeet plant (Chenopodium anthelminthicum)

Arabacı, Gülnur; Ayse Usluoglu (TAYLOR & FRANCIS INC, 2010)
The first total synthesis of apigenin 7-O--D-cellobiosyl-4-O--D-glucopyranoside isolated from Salvia uliginosa

Sönmez, Fatih; Nebioğlu, Mehmet; Beşoluk, Şenol; Arslan, Mustafa; Zengin, Mustafa; Küçükislamoğlu, Mustafa (TAYLOR & FRANCIS LTD, 2013)

The first total synthesis of apigenin 7-O--D-cellobioside (5) and apigenin 7-O--D-cellobiosyl-4-O--D-glucopyranoside (8), which were isolated from petals of Salvia patens and Salvia uliginosa, were achieved in four and six ...