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SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors

Salih Okten; Makbule Ekiz; Tutar, Ahmet; Burcu Butun; Umit Muhammet Kocyigit; Gulacti Topcu; Ilhami Gulcin (ASSOC PHARMACEUTICAL TEACHERS INDIA, 2019)

Background: The inhibition of both hydrolysis products of acetylcholine (ACh), Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE), is essential for successful treatment of Alzhemier patients. Objectives: This ...