Browsing Temel Tıp Bilimleri / Basic Medical Sciences by Author "Eskiler, GG;"

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Talazoparib to treat BRCA-positive breast cancer

Güney Eskiler, Gamze (PROUS SCIENCE, SAU-THOMSON REUTERS, 2019)

Talazoparib tosylate (BMN-673, Talzenna; Pfizer) is an oral poly [ADP-ribose] polymerase (PARP) inhibitor (PARPi) that has been approved by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) ...
The Interaction of PI3K Inhibition with Homologous Recombination Repair in Triple Negative Breast Cancer Cells

Güney Eskiler, Gamze (CANADIAN SOC PHARMACEUTICAL SCIENCES, 2019)

Purpose: Aberrant activation of the phosphatidylinositol 3'-kinase (PI3K)-Akt signaling pathway is observed in many types of human cancer including triple negative breast cancer (TNBC). Additionally, dysregulation in the ...