Browsing Fakülteler / Faculties by Author "Burcu Butun"

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SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors

Salih Okten; Makbule Ekiz; Tutar, Ahmet; Burcu Butun; Umit Muhammet Kocyigit; Gulacti Topcu; Ilhami Gulcin (ASSOC PHARMACEUTICAL TEACHERS INDIA, 2019)

Background: The inhibition of both hydrolysis products of acetylcholine (ACh), Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE), is essential for successful treatment of Alzhemier patients. Objectives: This ...
Synthesis, characterization, and SAR of arylated indenoquinoline-based cholinesterase and carbonic anhydrase inhibitors

Makbule Ekiz; Tutar, Ahmet; Salih Okten; Burcu Butun; Umit M. Kocyigit; Parham Taslimi; Guelacti Topcu (WILEY-V C H VERLAG GMBH, 2018)

We report the synthesis of bromoindenoquinolines (15a-f) by Friedlander reactions in low yields (13-50%) and the conversion of the corresponding phenyl-substituted indenoquinoline derivatives 16-21 in high yields (80-96%) ...