dc.contributor.authors |
Ozdemir, Ozlem; Zengel, Baha; Yildiz, Yasar; Uluc, Basak Oyan; Cabuk, Devrim; Ozden, Ercan; Salim, Derya Kivrak; Paydas, Semra; Demir, Atakan; Diker, Omer; Pilanci, Kezban Nur; Sonmez, Ozlem Uysal; Vatansever, Sezai; Dogan, Izzet; Gulmez, Ahmet; Cakar, Burcu; Gursoy, Pinar; Yildirim, Mahmut Emre; Ayhan, Murat; Karadurmus, Nuri; Aykan, Musa Baris; Cevik, Gokcen Tugba; Sakalar, Teoman; Hacibekiroglu, Ilhan; Gulbagci, Burcu Belen; Dincer, Murat; Garbioglu, Duygu Bayir; Kemal, Yasemin; Nayir, Erdinc; Taskaynatan, Halil; Yilmaz, Mesut; Avci, Okan; Sari, Murat; Coban, Ezgi; Atci, Muhammed Mustafa; Esen, Selin Akturk; Telli, Tugba Akin; Karatas, Fatih; Inal, Ali; Demir, Hacer; Kalkan, Nurhan Onal; Yilmaz, Cengiz; Tasli, Funda; Alacacioglu, Ahmet |
|
dc.date.accessioned |
2022-12-20T13:25:41Z |
|
dc.date.available |
2022-12-20T13:25:41Z |
|
dc.date.issued |
2022 |
|
dc.identifier.issn |
0959-4973 |
|
dc.identifier.uri |
http://dx.doi.org/10.1097/CAD.0000000000001310 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12619/99415 |
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dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
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dc.description.abstract |
In our study, we aimed to evaluate the pathological response rates and side effect profile of adding pertuzumab to the treatment of HER2+ locally advanced, inflammatory, or early-stage breast cancer. This study was conducted by the Turkish Oncology Group (TOG) with data collected from 32 centers. Our study was multicentric, and a total of 364 patients were included. The median age of the patients was 49 years (18-85 years). Two hundred fifteen (60%) of the cases were hormone receptor/HER2+ positive(ER+ or PR+, or both), and 149 (40%) of them were HER2-rich (ER and PR negative). The number of complete responses was 124 (54%) in the docetaxel+trastuzumab+pertuzumab arm and 102 (45%) in the paclitaxel+trastuzumab+pertuzumab arm, and there was no difference between the groups in terms of complete response. In 226 (62%) patients with complete response, a significant correlation was found with DCIS, tumor focality, removed lymph node, and ER status P < 0.05. Anemia, nausea, vomiting, myalgia, alopecia, and mucosal inflammation were significantly higher in the docetaxel arm, P < 0.05. In our study, no statistical difference was found between the before-after echocardiography values. DCIS positivity in biopsy before neoadjuvant chemotherapy, tumor focality; the number of lymph nodes removed and ER status were found to be associated with pCR. In conclusion, we think that studies evaluating pCR-related clinicopathological variables and radiological imaging features will play a critical role in the development of nonsurgical treatment approaches. |
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dc.language |
English |
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dc.language.iso |
eng |
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dc.relation.isversionof |
10.1097/CAD.0000000000001310 |
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dc.subject |
Oncology |
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dc.subject |
Pharmacology & Pharmacy |
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dc.subject |
breast cancer |
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dc.subject |
neoadjuvant chemotherapy |
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dc.subject |
pathological response |
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dc.subject |
pertuzumab |
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dc.title |
The effectiveness and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early-stage human epidermal growth factor receptor 2-positive breast cancer: Turkish Oncology Group study |
|
dc.contributor.authorID |
Doğan, İzzet/0000-0003-1018-1119 |
|
dc.contributor.authorID |
Diker, Omer/0000-0001-7162-4812 |
|
dc.contributor.authorID |
Akin Telli, Tugba/0000-0001-6535-6030 |
|
dc.contributor.authorID |
Paydas, Semra/0000-0003-4642-3693 |
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dc.identifier.volume |
33 |
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dc.identifier.startpage |
663 |
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dc.identifier.endpage |
670 |
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dc.relation.journal |
ANTI-CANCER DRUGS |
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dc.identifier.issue |
7 |
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dc.identifier.doi |
10.1097/CAD.0000000000001310 |
|
dc.identifier.eissn |
1473-5741 |
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dc.contributor.author |
Ozdemir, Ozlem |
|
dc.contributor.author |
Zengel, Baha |
|
dc.contributor.author |
Yildiz, Yasar |
|
dc.contributor.author |
Uluc, Basak Oyan |
|
dc.contributor.author |
Cabuk, Devrim |
|
dc.contributor.author |
Ozden, Ercan |
|
dc.contributor.author |
Salim, Derya Kivrak |
|
dc.contributor.author |
Paydas, Semra |
|
dc.contributor.author |
Demir, Atakan |
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dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
|