dc.contributor.authors |
Yilmaz, Dogukan; Yilmaz, Neslihan; Polat, Recep; Nissila, Verneri; Aydin, Elif Gul; Rautava, Jaana; Gursoy, Mervi; Gursoy, Ulvi Kahraman |
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dc.date.accessioned |
2022-12-20T13:25:14Z |
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dc.date.available |
2022-12-20T13:25:14Z |
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dc.date.issued |
2022 |
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dc.identifier.issn |
1432-6981 |
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dc.identifier.uri |
http://dx.doi.org/10.1007/s00784-022-04457-2 |
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dc.identifier.uri |
https://hdl.handle.net/20.500.12619/99251 |
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dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
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dc.description.abstract |
Objectives Type 1 diabetes mellitus (T1DM), a chronic autoimmune disease characterized by insulin deficiency, is related to periodontal diseases in children and adolescents. Our aim was to profile salivary human beta-defensin (hBD)-2 and hBD-3 concentrations in relation to periodontal and T1DM status in children and adolescent populations. Material and methods Unstimulated saliva samples were collected from 66 participants including periodontally healthy T1DM patients (T1DM + C; n = 18), T1DM patients with gingivitis (T1DM + G; n = 20), systemically and periodontally healthy individuals (SH + C: n = 15), and systemically healthy gingivitis patients (SH + G; n = 13). Full mouth plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded. Salivary hBD-2 and hBD-3 concentrations were evaluated by sandwich ELISA method. A p value of < 0.05 was considered statistically significant. Results Salivary hBD-3 concentrations were lower in T1DM groups in comparison to systemically healthy counterparts (SH + G vs. T1DM + G; p < 0.001 and SH + C vs. T1DM + C; p < 0.001). Salivary hBD-2 levels did not differ between related groups. The difference in hBD-3 concentrations between T1DM and control groups was still significant (p = 0.008) after being adjusted for PI%, BOP%, and age. Conclusion In the limits of study, T1DM patients were found to have decreased salivary hBD-3 concentrations, regardless of their gingival inflammatory status. |
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dc.language |
English |
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dc.language.iso |
eng |
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dc.relation.isversionof |
10.1007/s00784-022-04457-2 |
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dc.subject |
Dentistry, Oral Surgery & Medicine |
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dc.subject |
Type 1 diabetes mellitus |
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dc.subject |
Gingivitis |
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dc.subject |
Antimicrobial |
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dc.subject |
Saliva |
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dc.title |
Salivary levels of hBDs in children and adolescents with type 1 diabetes mellitus and gingivitis |
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dc.contributor.authorID |
GUL AYDIN, Elif/0000-0002-6034-0029 |
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dc.contributor.authorID |
Gursoy, Mervi/0000-0001-8545-6821 |
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dc.contributor.authorID |
YILMAZ, Neslihan/0000-0001-7939-9525 |
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dc.contributor.authorID |
Polat, Recep/0000-0002-3786-0739 |
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dc.contributor.authorID |
Nissila, Verneri/0000-0002-4005-6530 |
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dc.identifier.volume |
26 |
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dc.identifier.startpage |
4897 |
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dc.identifier.endpage |
4904 |
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dc.relation.journal |
CLINICAL ORAL INVESTIGATIONS |
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dc.identifier.issue |
7 |
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dc.identifier.doi |
10.1007/s00784-022-04457-2 |
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dc.identifier.eissn |
1436-3771 |
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dc.contributor.author |
Yilmaz, Dogukan |
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dc.contributor.author |
Yilmaz, Neslihan |
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dc.contributor.author |
Polat, Recep |
|
dc.contributor.author |
Nissila, Verneri |
|
dc.contributor.author |
Aydin, Elif Gul |
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dc.contributor.author |
Rautava, Jaana |
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dc.contributor.author |
Gursoy, Mervi |
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dc.contributor.author |
Gursoy, Ulvi Kahraman |
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dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
|