An innovative layer-by-layer coated titanium hydroxide-(gentamicin-polydopamine) as a hybrid drug delivery platform

Abstract

This work developed an innovative hybrid inorganic-organic-drug multilayer coating process to improve drug release time from the coating surface. The feasibility of chemical in situ self-polymerization of polydopamine (PDA) layer on nanostructured titanium hydroxide (TiOH) surface was investigated. The drug delivery platform containing gentamicin (Gent) was obtained and compared with two different layer-by-layer coating methods, both non-simultaneous and simultaneous. Through the XRD, FTIR, and EDS, the main components of the pretreated surface were identified as nanostructured TiOH. The surface morphology, chemical composition, drug release kinetics, and zeta potentials of the obtained multilayers were investigated by FESEM, SEM, EDS, FTIR, UV-Vis, and Zetasizer. The multilayer hybrid drug delivery platforms demonstrated a prolonged drug release and in vitro inhibitory effect on the growth of the S. aureus. In addition, the bioactivity of the coatings was examined after the bio-mineralization process in the simulated body fluid. In conclusion, the developed TiOH-(Gent-PDA) surface coating system shows great potential for improving self-antibacterial performance, bioactivity, and longevity of Ti-based biomaterials.