dc.date.accessioned |
2021-06-08T09:12:01Z |
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dc.date.available |
2021-06-08T09:12:01Z |
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dc.date.issued |
2020 |
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dc.identifier.issn |
0001-6357 |
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dc.identifier.uri |
https://hdl.handle.net/20.500.12619/96172 |
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dc.description |
This work was supported by Sakarya University Scientific Research Projects Coordination Unit under grant number: 2019-5-19-61. |
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dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
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dc.description.abstract |
Objective: Type 2 diabetes mellitus (T2DM) is a well-defined risk factor of periodontitis and it can affect expression of human beta-defensins (hBDs) and cathelicidin (LL-37) as well. The aim of the present study was to evaluate the impact of periodontitis and T2DM on salivary concentrations of these antimicrobial peptides. Material and methods: Unstimulated saliva samples, together with full-mouth periodontal recordings were collected from 92 individuals with periodontitis (63 with T2DM and 21 smokers) and 86 periodontally healthy controls (58 with T2DM and 21 smokers). Salivary hBD-1, -2, -3, LL-37, and advanced glycalization end products (AGE) concentrations were measured by enzyme-linked immunosorbent assay. Results: Among the periodontitis patients, T2DM group demonstrated lower levels of hBD-1 (p = .006), hBD-2 (p < .001) and hBD-3 (p < .001), and higher levels of LL-37 (p < .001) compared to systemically healthy controls. When only periodontally healthy controls were included into the analysis, higher hBD-1 (p = .002) and LL-37 (p < .001) levels were found in T2DM patients in comparison to systemically healthy controls. Salivary LL-37 levels were associated with HbA1c and periodontitis, while hBD-2, hBD-3 and levels associated only with HbA1c. Conclusion: In the limits of this study, hyperglycaemia can be proposed as a regulator of salivary hBD and cathelicidin levels. Periodontitis, on the other hand, affects only salivary LL-37 levels. |
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dc.description.sponsorship |
Sakarya University Scientific Research Projects Coordination UnitSakarya University [2019-5-19-61] |
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dc.language |
English |
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dc.language.iso |
eng |
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dc.publisher |
TAYLOR & FRANCIS LTD |
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dc.relation.isversionof |
10.1080/00016357.2020.1715471 |
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dc.rights |
info:eu-repo/semantics/closedAccess |
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dc.subject |
CREVICULAR FLUID LEVELS |
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dc.subject |
RISK-FACTORS |
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dc.subject |
EXPRESSION |
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dc.subject |
DISEASES |
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dc.subject |
LL-37 |
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dc.title |
Salivary human beta-defensins and cathelicidin levels in relation to periodontitis and type 2 diabetes mellitus |
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dc.type |
Article |
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dc.contributor.authorID |
Altindis, Mustafa/0000-0003-0411-9669 |
|
dc.contributor.authorID |
Yilmaz, Dogukan/0000-0003-2576-0885 |
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dc.contributor.authorID |
Gursoy, Ulvi Kahraman/0000-0002-1225-5751 |
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dc.identifier.volume |
78 |
|
dc.identifier.startpage |
327 |
|
dc.identifier.endpage |
331 |
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dc.relation.journal |
ACTA ODONTOLOGICA SCANDINAVICA |
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dc.identifier.issue |
5 |
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dc.identifier.doi |
10.1080/00016357.2020.1715471 |
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dc.identifier.eissn |
1502-3850 |
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dc.contributor.author |
Yilmaz, Dogukan |
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dc.contributor.author |
Topcu, Ali Orkun |
|
dc.contributor.author |
Akcay, Emine Ulku |
|
dc.contributor.author |
Altindis, Mustafa |
|
dc.contributor.author |
Gursoy, Ulvi Kahraman |
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dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
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dc.identifier.pmıd |
31980002 |
|