dc.date.accessioned |
2021-06-08T09:11:19Z |
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dc.date.available |
2021-06-08T09:11:19Z |
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dc.identifier.issn |
1381-3455 |
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dc.identifier.uri |
https://hdl.handle.net/20.500.12619/95852 |
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dc.description |
This study was supported by opportunities from the Department of Biochemistry, Faculty of Medicine, Van Yuzuncu Yil University and Department of Pathology, Faculty of Veterinary, Ataturk University. |
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dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
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dc.description.abstract |
Objective: This study investigated effect of zaprinast and avanafil on vascular endothelial growth factor (VEGF), bone morphogenic protein (BMP) 4 and 7, and vitamin D-3 levels against the negative effect of dexamethazone. Method: Rats were randomly divided into four groups (n = 6). Control: Empty a syringe was immersed and removed subcutaneously. Dexamethasone (DEX): 120 mu g/kg DEX was injected subcutaneously once a day for 28 days. DEX + zaprinast and DEX + avanafil groups: 10 mg/kg zaprinast and avanafil were administrated to rats in addition to the same procedure in the DEX, respectively. VitaminD(3), VEGF, BMP4 and 7 levels by enzyme linked immunosorbent assay (ELISA) and angiogenesis by histopathological/immunohistochemical were evaluated. Results: BMP4 values in the DEX were lower than the other groups (p < .05). DEX + zaprinast and DEX + avanafil exhibited an increase in all the parameters compared to the control and DEX (p < .05). However, these were not significant for the DEX + zaprinast (p > .05). Also, there was a significant increase in angiogenesis in the DEX + zaprinast and DEX + avanafil. Conclusion: Zaprinast and significantly avanafil induced vitamin D-3, BMP4 and 7 levels by increasing angiogenesis in renal. |
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dc.description.sponsorship |
Department of Biochemistry, Faculty of Medicine, Van Yuzuncu Yil University; Department of Pathology, Faculty of Veterinary, Ataturk University |
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dc.language |
English |
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dc.language.iso |
eng |
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dc.publisher |
TAYLOR & FRANCIS LTD |
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dc.relation.isversionof |
10.1080/13813455.2020.1767149 |
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dc.rights |
info:eu-repo/semantics/closedAccess |
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dc.subject |
1,25-DIHYDROXYVITAMIN D-3 |
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dc.subject |
PHOSPHODIESTERASE-5 INHIBITOR |
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dc.subject |
OXIDATIVE DAMAGE |
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dc.subject |
VEGF |
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dc.subject |
EXPRESSION |
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dc.subject |
DIFFERENTIATION |
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dc.subject |
ACCUMULATION |
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dc.subject |
MODEL |
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dc.subject |
BMP-2 |
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dc.title |
Zaprinast and avanafil increase the vascular endothelial growth factor, vitamin D-3, bone morphogenic proteins 4 and 7 levels in the kidney tissue of male rats applied the glucocorticoid |
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dc.type |
Article; Early Access |
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dc.relation.journal |
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY |
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dc.identifier.doi |
10.1080/13813455.2020.1767149 |
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dc.identifier.eissn |
1744-4160 |
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dc.contributor.author |
Huyut, Zubeyir |
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dc.contributor.author |
Bakan, Nuri |
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dc.contributor.author |
Akbay, Halil Ibrahim |
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dc.contributor.author |
Yildirim, Serkan |
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dc.contributor.author |
Sekeroglu, Mehmet Ramazan |
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dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
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dc.identifier.pmıd |
32421396 |
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