dc.date.accessioned |
2021-06-08T09:11:16Z |
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dc.date.available |
2021-06-08T09:11:16Z |
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dc.identifier.issn |
1381-3455 |
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dc.identifier.uri |
https://hdl.handle.net/20.500.12619/95809 |
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dc.description |
This study was supported by opportunities from the Department of Biochemistry, Faculty of Medicine, Van Yuzuncu Yil University and Department of Pathology, Faculty of Veterinary, Ataturk University. |
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dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
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dc.description.abstract |
Objective: This study investigated the effect of vardenafil, tadalafil, and udenafil from phosphodiesterase-5 inhibitors (PDE-5Is) on bone morphogenic-protein (BMP)2 and 4 levels, along with angiogenesis in ovariectomized rat's kidney. Method: Rats were randomly divided into five groups (n = 10). Sham: abdomen was opened, and closed. OVX: ovaries were removed. OVX + vardenafil, OVX + tadalafil, and OVX + udenafil groups: ovaries were removed and closed, and after 6 months from postoperative, 10 mg/kg of vardenafil, tadalafil, and udenafil were administrated as daily a single-dose for 60 days, respectively. Histopathologic and immunohistochemical examinations were performed for angiogenesis, and biochemical analysis for vascular endothelial growth-factor (VEGF), VitaminD(3), BMP2 and 4 levels in rat's kidney. Results: VEGF, BMP2 and 4, VitaminD(3), and angiogenesis were high in the all inhibitor groups compared with the sham and OVX (p < .05). However, BMP4 levels were only high in the OVX + tadalafil group (p < .05). Conclusion: The results indicated that vardenafil, udenafil, and especially tadalafil increased VEGF, BMP2, and VitaminD(3) levels. |
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dc.description.sponsorship |
Department of Biochemistry, Faculty of Medicine, Van Yuzuncu Yil University; Department of Pathology, Faculty of Veterinary, Ataturk University |
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dc.language |
English |
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dc.language.iso |
eng |
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dc.publisher |
TAYLOR & FRANCIS LTD |
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dc.relation.isversionof |
10.1080/13813455.2020.1755695 |
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dc.rights |
info:eu-repo/semantics/closedAccess |
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dc.subject |
1,25-DIHYDROXYVITAMIN D-3 |
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dc.subject |
OXIDATIVE DAMAGE |
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dc.subject |
INHIBITORS |
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dc.subject |
DIFFERENTIATION |
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dc.subject |
EXPRESSION |
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dc.subject |
BMP-2 |
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dc.subject |
VEGF |
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dc.title |
Stimulating effects of vardenafil, tadalafil, and udenafil on vascular endothelial growth factor, angiogenesis, vitamin D-3, bone morphogenic proteins in ovariectomized rats |
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dc.type |
Article; Early Access |
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dc.contributor.authorID |
alp, hamit hakan/0000-0002-9202-4944 |
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dc.relation.journal |
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY |
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dc.identifier.doi |
10.1080/13813455.2020.1755695 |
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dc.identifier.eissn |
1744-4160 |
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dc.contributor.author |
Huyut, Zubeyir |
|
dc.contributor.author |
Alp, Hamit Hakan |
|
dc.contributor.author |
Bakan, Nuri |
|
dc.contributor.author |
Yildirim, Serkan |
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dc.contributor.author |
Sekeroglu, Mehmet Ramazan |
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dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
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dc.identifier.pmıd |
32314927 |
|