dc.date.accessioned |
2021-06-08T09:11:12Z |
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dc.date.available |
2021-06-08T09:11:12Z |
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dc.identifier.issn |
1381-3455 |
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dc.identifier.uri |
https://hdl.handle.net/20.500.12619/95743 |
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dc.description |
This study was supported by Presidency of the Individual Research Projects, Van Yuzuncu Yil University [2002-TF-087] and with opportunities from the Department of Biochemistry, Faculty of Medicine. |
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dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
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dc.description.abstract |
Objective: This study investigated the relationship between diabetes (DM) and nitrite, nitrate and MDA levels and effect of melatonin and pentoxifylline. Methods: Sixty mice were randomly divided into four groups. Control: no action; Diabetes group (DM): after fasting-blood-glucose (FBG) was measured, 150 mg/kg alloxane was applied intraperitoneally three-times every other day; Diabetes + Melatonin (DM + MLT) and Diabetes + Pentoxifylline groups (DM + PTX): following the same procedures with DM, 10 mg/kg melatonin and 50 mg/kg pentoxifylline were administered subcutaneously six days, respectively. Following FBG analysis, brain tissues were taken under the anaesthesia. Nitrite, nitrate and MDA levels were measured. Results: In the all groups with alloxane, FBG were higher than in before application (p < .05). Also, FBG, nitrite, nitrate and MDA levels in the DM + MLT and DM + PTX groups were lower than in the DM (p < .05). Conclusions: Nitrite and nitrate may be related to etiopathogenesis of DM, and pentoxifylline and especially melatonin relatively decrease nitrite, nitrate and lipid peroxidation. |
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dc.description.sponsorship |
Van Yuzuncu Yil UniversityYuzuncu Yil University [2002-TF-087] |
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dc.language |
English |
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dc.language.iso |
eng |
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dc.publisher |
TAYLOR & FRANCIS LTD |
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dc.relation.isversionof |
10.1080/13813455.2020.1727528 |
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dc.rights |
info:eu-repo/semantics/closedAccess |
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dc.subject |
RED-BLOOD-CELLS |
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dc.subject |
FLUOROMETRIC-DETERMINATION |
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dc.subject |
OXIDATIVE STRESS |
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dc.subject |
SUSCEPTIBILITY |
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dc.subject |
SERUM |
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dc.subject |
PROTEIN |
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dc.subject |
DAMAGE |
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dc.subject |
ACID |
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dc.subject |
NO |
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dc.title |
The levels of nitrite, nitrate and lipid peroxidation in diabetic mouse brain: the effect of melatonin and pentoxifylline |
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dc.type |
Article; Early Access |
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dc.contributor.authorID |
Ozbek, Hanefi/0000-0002-8084-7855 |
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dc.contributor.authorID |
cokluk, erdem/0000-0002-6205-5109 |
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dc.relation.journal |
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY |
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dc.identifier.doi |
10.1080/13813455.2020.1727528 |
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dc.identifier.eissn |
1744-4160 |
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dc.contributor.author |
Yalcinkaya, Ahmet S. |
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dc.contributor.author |
Sekeroglu, Mehmet Ramazan |
|
dc.contributor.author |
Huyut, Zubeyir |
|
dc.contributor.author |
Cokluk, Erdem |
|
dc.contributor.author |
Ozbek, Hanefi |
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dc.contributor.author |
Ozturk, Gurkan |
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dc.contributor.author |
Balahoroglu, Ragip |
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dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
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dc.identifier.pmıd |
32070146 |
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