dc.date.accessioned |
2021-06-03T11:02:30Z |
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dc.date.available |
2021-06-03T11:02:30Z |
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dc.date.issued |
2021 |
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dc.identifier.issn |
2213-2317 |
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dc.identifier.uri |
https://www.doi.org/10.1016/j.redox.2020.101744 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12619/95523 |
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dc.description |
This work was supported by NIH grants: AI145406, CA165065, AI068021, GM113908, HL114453, AI156924, NS076511, AI156923, NS061817; National Science Centre, Poland Grant (2019/35/D/ST4/02203), Natural Science Foundation of China (81873209, 81622050, 81903821); 111 Project of Chinese MoE (B13038); the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2017BT01Y036), and GDUPS (2019). |
|
dc.description |
Bu yayın 06.11.1981 tarihli ve 17506 sayılı Resmî Gazete’de yayımlanan 2547 sayılı Yükseköğretim Kanunu’nun 4/c, 12/c, 42/c ve 42/d maddelerine dayalı 12/12/2019 tarih, 543 sayılı ve 05 numaralı Üniversite Senato Kararı ile hazırlanan Sakarya Üniversitesi Açık Bilim ve Açık Akademik Arşiv Yönergesi gereğince açık akademik arşiv sistemine açık erişim olarak yüklenmiştir. |
|
dc.description |
Bu yayın 06.11.1981 tarihli ve 17506 sayılı Resmî Gazete’de yayımlanan 2547 sayılı Yükseköğretim Kanunu’nun 4/c, 12/c, 42/c ve 42/d maddelerine dayalı 12/12/2019 tarih, 543 sayılı ve 05 numaralı Üniversite Senato Kararı ile hazırlanan Sakarya Üniversitesi Açık Bilim ve Açık Akademik Arşiv Yönergesi gereğince açık akademik arşiv sistemine açık erişim olarak yüklenmiştir. |
|
dc.description.abstract |
Hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) is a fermptotic cell death signal. HpETE-PE is produced by the 15-Lipoxygenase (15LOX)/Phosphatidylethanolamine Binding Protein-1 (PEBP1) complex or via an Fe-catalyzed non-enzymatic radical reaction. Ferrostatin-1 (Fer-1), a common ferroptosis inhibitor, is a lipophilic radical scavenger but a poor 15LOX inhibitor arguing against 15LOX having a role in fermptosis. In the current work, we demonstrate that Fer-1 does not affect 15LOX alone, however, it effectively inhibits HpETE-PE production by the 15LOX/PEBP1 complex. Computational molecular modeling shows that Fer-1 binds to the 15LOX/PEBP1 complex at three sites and could disrupt the catalytically required allosteric motions of the 15LOX/PEBP1 complex. Using nine fermptosis cell/tissue models, we show that HpETE-PE is produced by the 15LOX/PEBP1 complex and resolve the long-existing Fer-1 anti-ferroptotic paradox. |
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dc.description.sponsorship |
NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [AI145406, CA165065, AI068021, GM113908, HL114453, AI156924, NS076511, AI156923, NS061817] |
|
dc.description.sponsorship |
National Science Centre, PolandNational Science Centre, Poland [2019/35/D/ST4/02203] |
|
dc.description.sponsorship |
Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81873209, 81622050, 81903821] |
|
dc.description.sponsorship |
111 Project of Chinese MoE [B13038] |
|
dc.description.sponsorship |
Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01Y036] |
|
dc.language |
English |
|
dc.language.iso |
eng |
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dc.publisher |
ELSEVIER |
|
dc.relation.isversionof |
10.1016/j.redox.2020.101744 |
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dc.rights |
info:eu-repo/semantics/openAccess |
|
dc.subject |
Ferroptosis |
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dc.subject |
Ferrostatin-1 |
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dc.subject |
15-Lipoxygenase |
|
dc.subject |
Hydroperoxy-eicosatetraenoyl-phosphatidylethanolamines |
|
dc.subject |
Phospholipid peroxidation |
|
dc.title |
Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis |
|
dc.type |
Article |
|
dc.contributor.authorID |
Mikulska-Ruminska, Karolina/0000-0001-7227-5503 |
|
dc.contributor.authorID |
VanDemark, Andrew/0000-0003-3424-4831 |
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dc.identifier.volume |
38 |
|
dc.relation.journal |
REDOX BIOLOGY |
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dc.identifier.wos |
WOS:000604901500005 |
|
dc.identifier.doi |
10.1016/j.redox.2020.101744 |
|
dc.contributor.author |
Anthonymuthu, Tamil S. |
|
dc.contributor.author |
Tyurina, Yulia Y. |
|
dc.contributor.author |
Sun, Wan-Yang |
|
dc.contributor.author |
Mikulska-Ruminska, Karolina |
|
dc.contributor.author |
Shrivastava, Indira H. |
|
dc.contributor.author |
Tyurin, Vladimir A. |
|
dc.contributor.author |
Cinemre, Fatma B. |
|
dc.contributor.author |
Dar, Haider H. |
|
dc.contributor.author |
VanDemark, Andrew P. |
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dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
|
dc.identifier.pmıd |
33126055 |
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dc.rights.openaccessdesignations |
DOAJ Gold, Green Published |
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