Abstract:
Objective: In this study, we aimed to determine the factors that contribute to the early determination of mortality risk in patients hospitalized with COVID-19. Methods: We included 941 adult inpatients (474 male [50.4%], mean age, 53.5 +/- 17.0. The patients were divided into two groups: the discharge group and the death group. Epidemiological data, medical history, underlying comorbidities, laboratory findings, chest computed tomographic scans, real-time reverse transcription polymerase chain reaction detection results, and survival data were obtained with retrospective recordings on admission and follow-up. The statistical relationship between survival data and parameters was analyzed. A mathematical model was created from the data of both groups. Results: While 863 patients survived, 78 were non-survivors. During the study period, the preliminary case fatality rate of the inpatients was 8.3%. The mean age of the non-survivors was 71.7 +/- 11.2 SD (P<0.001). Laboratory findings showed that mortality was high in those with high D-dimer, sodium, lactate dehydrogenase (LDH), troponin, creatine kinase-myocardial band (CK-MB), ferritin, blood lactate, activated partial thromboplastin time, and high blood glucose levels (P<0.05). Furthermore, mortality was high in patients with low albumin, lymphocyte, and platelet levels (P<0.05). The logistic regression model showed that advanced age, hypertension, high D-Dimer (>1000 ng/ml), high C-reactive protein (CRP), CK-MB, and LDH, and low lymphocyte count were associated with poor prognosis. Conclusions: According to week 1 data of patients with COVID-19, advanced age, hypertension, D-Dimer, CRP, CK-MB, high LDH, and low lymphocyte were associated with poor prognosis. We believe that this model will be useful in predicting patient mortality.
Description:
We would like to thank the Sakarya Training and Research Hospital and the Infection Control Committee for their support in this research.
Bu yayın 06.11.1981 tarihli ve 17506 sayılı Resmî Gazete’de yayımlanan 2547 sayılı Yükseköğretim Kanunu’nun 4/c, 12/c, 42/c ve 42/d maddelerine dayalı 12/12/2019 tarih, 543 sayılı ve 05 numaralı Üniversite Senato Kararı ile hazırlanan Sakarya Üniversitesi Açık Bilim ve Açık Akademik Arşiv Yönergesi gereğince açık akademik arşiv sistemine açık erişim olarak yüklenmiştir.
Bu yayın 06.11.1981 tarihli ve 17506 sayılı Resmî Gazete’de yayımlanan 2547 sayılı Yükseköğretim Kanunu’nun 4/c, 12/c, 42/c ve 42/d maddelerine dayalı 12/12/2019 tarih, 543 sayılı ve 05 numaralı Üniversite Senato Kararı ile hazırlanan Sakarya Üniversitesi Açık Bilim ve Açık Akademik Arşiv Yönergesi gereğince açık akademik arşiv sistemine açık erişim olarak yüklenmiştir.