dc.rights.license |
DOAJ Gold |
|
dc.date.accessioned |
2021-06-03T08:20:16Z |
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dc.date.available |
2021-06-03T08:20:16Z |
|
dc.date.issued |
2020 |
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dc.identifier.uri |
www.doi.org/10.1590/1806-9282.66.12.1666 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12619/95120 |
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dc.description |
Bu yayın 06.11.1981 tarihli ve 17506 sayılı Resmî Gazete’de yayımlanan 2547 sayılı Yükseköğretim Kanunu’nun 4/c, 12/c, 42/c ve 42/d maddelerine dayalı 12/12/2019 tarih, 543 sayılı ve 05 numaralı Üniversite Senato Kararı ile hazırlanan Sakarya Üniversitesi Açık Bilim ve Açık Akademik Arşiv Yönergesi gereğince açık akademik arşiv sistemine açık erişim olarak yüklenmiştir. |
|
dc.description.abstract |
BACKGROUND: The COVID-19 pandemic has affected the entire world, posing a serious threat to human health. T cells play a critical role in the cellular immune response against viral infections. We aimed to reveal the relationship between T cell subsets and disease severity. METHODS: 40 COVID-19 patients were randomly recruited in this cross-sectional study. All cases were con firmed by quantitative RT-PCR. Patients were divided into two equivalent groups, one severe and one nonsevere. Clinical, laboratory and flow cytometric data were obtained from both clinical groups and compared. RESULTS: Lymphocyte subsets, CD4+ and CD8+ T cells, memory CD4+ T cells, memory CD8+ T cells, naive CD4+ T cells, effector memory CD4+ T cells, central memory CD4+ T cells, and CD3+CD4+ CD25+ T cells were significantly lower in severe patients. The naive T cell/CD4 + EM T cell ratio, which is an indicator of the differentiation from naive T cells to memory cells, was relatively reduced in severe disease. Peripheral CD4+CD8+ double-positive T cells were notably lower in severe presentations of the disease (median DP T cells 11.12 mu L vs 1.95 mu L; p< 0.001). CONCLUSIONS: As disease severity increases in COVID-19 infection, the number of T cell subsets decreases significantly. Suppression of differentiation from naive T cells to effector memory T cells is the result of severe impairment in adaptive immune functions. Peripheral CD4+CD8+ double-positive T cells were significantly reduced in severe disease presentations and may be a useful marker to predict disease severity. |
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dc.language |
English |
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dc.language.iso |
İngilizce |
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dc.publisher |
ASSOC MEDICA BRASILEIRA |
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dc.relation.isversionof |
10.1590/1806-9282.66.12.1666 |
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dc.rights |
info:eu-repo/semantics/openAccess |
|
dc.subject |
ANTIBODY-RESPONSES |
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dc.subject |
CYTOKINE STORM |
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dc.subject |
CORONAVIRUS |
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dc.subject |
BLOOD |
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dc.subject |
COVID-19 |
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dc.subject |
Lymphocyte Subsets |
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dc.subject |
Adaptive Immunity |
|
dc.title |
Comparative evaluation of memory T cells in COVID-19 patients and predictive role of CD4(+)CD8(+) double positive T lymphocytes as a new marker |
|
dc.type |
Article |
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dc.contributor.authorID |
Varim, Ceyhun/0000-0002-8369-0857 |
|
dc.contributor.authorID |
Falay, Mesude/0000-0001-7846-3476 |
|
dc.contributor.authorID |
Sunu, Cenk/0000-0002-6513-6211 |
|
dc.contributor.authorID |
kocayigit, havva/0000-0002-8719-7031 |
|
dc.contributor.authorID |
Hacibekiroglu, Tuba/0000-0003-1814-5972 |
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dc.identifier.volume |
66 |
|
dc.identifier.startpage |
1666 |
|
dc.identifier.endpage |
1672 |
|
dc.relation.journal |
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA |
|
dc.identifier.issue |
12 |
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dc.identifier.wos |
WOS:000599837000013 |
|
dc.identifier.doi |
10.1590/1806-9282.66.12.1666 |
|
dc.identifier.eissn |
1806-9282 |
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dc.contributor.author |
Kalpakci, Yasin |
|
dc.contributor.author |
Hacibekiroglu, Tuba |
|
dc.contributor.author |
Trak, Gulay |
|
dc.contributor.author |
Karacaer, Cengiz |
|
dc.contributor.author |
Demirci, Taner |
|
dc.contributor.author |
Kocayigit, Havva |
|
dc.contributor.author |
Sunu, Cenk |
|
dc.contributor.author |
Varim, Ceyhun |
|
dc.contributor.author |
Falay, Mesude |
|
dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
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dc.identifier.pmıd |
33331574 |
|