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3-Chloro-4-fluorophenoxy substituted zinc phthalocyanine/graphene oxide composites: exploring of their sono-photochemical properties

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dc.date.accessioned 2023-08-02T13:26:43Z
dc.date.available 2023-08-02T13:26:43Z
dc.date.issued 2023
dc.identifier.issn 3666352
dc.identifier.uri https://www.scopus.com/inward/record.uri?eid=2-s2.0-85160846746&doi=10.1007%2fs11696-023-02892-3&partnerID=40&md5=7896cfb2654cd6d8b687267958b7366e
dc.identifier.uri https://www.scopus.com/inward/record.uri?eid=2-s2.0-85160846746&doi=10.1007%2fs11696-023-02892-3&partnerID=40&md5=7896cfb2654cd6d8b687267958b7366e
dc.identifier.uri https://hdl.handle.net/20.500.12619/101216
dc.description Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir.
dc.description.abstract The purpose of this paper is to determine the therapeutic contribution of graphene oxide (GO) to photo/sonosensitizers through photo-physicochemical and sono-photochemical studies for the first time. In this way, new zinc (II) phthalocyanine bearing 3-chloro-4-fluorophenoxy (2) was synthesized; and then, its graphene oxide (GO)-based composites were prepared by noncovalently coating ZnPc (2) on the graphene oxide surface. The photo-activity of these materials was compared and discussed in terms of their potential ability to be used in photosensitizer in photodynamic therapy (PDT) and sono-photodynamic therapy (SPDT). In these application areas, graphene oxide can serve as photosensitizer carrier, while ZnPc (2) can be acting as PDT/SPDT agent. Therefore, phthalocyanine composites containing different percentages of graphene oxide by weight (wt% GO) were prepared. SEM (scanning electron microscopy) results supported the interaction between GO and ZnPc (2). In the sono-photochemical study (SPDT), both ZnPc (2) and its composites gave very higher ?? values than the photochemical study (PDT). The sono-photochemical values were found to be 0.976 for 0 wt% GO, 0.961 for 0.25 wt% GO, 0.917 for 0.50 wt% GO, 0.910 for 1 wt% GO, 0.901 for 3 wt% GO, 0.890 for 5 wt% GO and 0.942 for 10 wt% GO, respectively. To the best of our knowledge, this is the first study of the use of phthalocyanines with GO by sonophotochemically as potential photosensitizers for sono-photodynamic therapy (SPDT) applications. According to obtained results, ZnPc (2) and its composites could be promise as good photosensitizers for both PDT and SPDT due to their very high singlet oxygen generation in both the photochemical study (PDT) and the sono-photochemical study (SPDT). Graphical abstract: In this work, a novel nonperipherally zinc (II) phthalocyanine bearing 3-chloro-4-fluorophenoxy (2) was synthesized and its graphene oxide (GO)-based composites was prepared by noncovalently coating novel ZnPc (2) on the GO surface. Afterward, the therapeutic contribution of GO to these new sono/photosensitizers through sono/photochemical studies is presented for the first time. [Figure not available: see fulltext.] © 2023, Institute of Chemistry, Slovak Academy of Sciences.
dc.language English
dc.language.iso eng
dc.relation.isversionof 10.1007/s11696-023-02892-3
dc.subject Graphene oxide
dc.subject Photosensitizer
dc.subject Phthalocyanine
dc.subject Sono-photodynamic therapy
dc.subject Synthesis
dc.title 3-Chloro-4-fluorophenoxy substituted zinc phthalocyanine/graphene oxide composites: exploring of their sono-photochemical properties
dc.title 3-Chloro-4-fluorophenoxy substituted zinc phthalocyanine/graphene oxide composites: exploring of their sono-photochemical properties
dc.type Article
dc.contributor.department Sakarya Üniversitesi, Fen Fakültesi, Kimya Bölümü
dc.relation.journal Chemical Papers
dc.identifier.doi 10.1007/s11696-023-02892-3
dc.contributor.author Günsel A.
dc.contributor.author Küçük M.C.
dc.contributor.author Günsel H.
dc.contributor.author Yaşa Atmaca G.
dc.contributor.author Bilgiçli A.T.
dc.contributor.author Erdoğmuş A.
dc.contributor.author Yarasir M.N.
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı


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