https://hdl.handle.net/20.500.12619/64997 2026-04-15T16:07:31Z 2026-04-15T16:07:31Z K Cagli Bağcı, Cahit M Gulec B Cengiz O Akyol https://hdl.handle.net/20.500.12619/65685 2020-03-03T11:25:43Z 2005-01-01T00:00:00Z

In vivo effects of caffeic acid phenethyl ester on myocardial ischemia-reperfusion injury and apoptotic changes in rats K Cagli; Bağcı, Cahit; M Gulec; B Cengiz; O Akyol Ischemia/reperfusion (I/R) has been reported to induce apoptotic cellular death in myocardium. This study tested the hypothesis that caffeic acid phenethyl ester ( CAPE), one of the active components of propolis, may ameliorate myocardial apoptosis and oxidative myocardial injury. Wistar rats were divided into 4 groups: (i) sham operated, (ii) I/R, (iii) I/R+ CAPE, and (iv) I/R+ glutathione (GSH). CAPE ( 10 mu mol/kg) was infused iv 10 min before occlusion of the left anterior descending coronary artery ( 30 min) followed by reperfusion ( 120 min). GSH ( 5 mg/kg) was infused iv after the occlusion and immediately before reperfusion. The TdT-mediated in situ nick end-labeling ( TUNEL) method was used to evaluate apoptotic activity. I/R resulted in myocardial apoptosis, alterations of antioxidant status, elevation of serum creatine kinase (CK) and aspartate aminotransferase (AST) activities, evidence of lipid peroxidation, and elevated nitric oxide levels, compared to the sham-operation group. No apoptotic cells were found in the myocardial tissue of sham-operated rats. The TUNEL-positive myocardial cells averaged 60%, 30%, and 40% in the I/R, I/R+ CAPE, and I/R+ GSH groups, respectively. This study demonstrates that pretreatment with CAPE provides cardio-protection from I/R injury. The I/R+ CAPE group showed reduced apoptosis, attenuated NO production, elevated myocardial superoxide dismutase ( SOD) activity, and diminished serum CK and AST activities, compared to the I/R group.

2005-01-01T00:00:00Z Bağcı, Cahit Aı Bozkurt Çakmak, Ecir Ali Can, Serra B Cengiz https://hdl.handle.net/20.500.12619/65683 2020-02-27T07:23:58Z 2005-01-01T00:00:00Z

Blood levels of the battery and exhaust workers and their pulmonary function tests (vol 58, pg 568, 2004) Bağcı, Cahit; Aı Bozkurt; Çakmak, Ecir Ali; Can, Serra; B Cengiz

2005-01-01T00:00:00Z Ceylan, Hasan M Yuncu A Gurel F Armutcu Hs Gergerlioglu Bağcı, Cahit At Demiryurek https://hdl.handle.net/20.500.12619/65684 2020-02-27T07:23:59Z 2005-01-01T00:00:00Z

Effects of whole-body hypoxic preconditioning on hypoxia/reoxygenation-induced intestinal injury in newborn rats Ceylan, Hasan; M Yuncu; A Gurel; F Armutcu; Hs Gergerlioglu; Bağcı, Cahit; At Demiryurek Purpose: The precise cause of necrotizing enterocolitis (NEC) is elusive. Ischemia and reperfusion injury of the intestine has been considered to be a major contributing factor for NEC. Ischemic preconditioning is defined as one or more brief periods of ischemia with intermittent reperfusion that protects tissues against a sustained period of subsequent ischemia. Contribution of preconditioning to hypoxia/reoxygenation-induced intestinal injury in newborn rats has not been evaluated previously. Methods: The study was carried out on 1-day-old Wistar albino rat pups. Whole-body hypoxia and reoxygenation (H/R) was achieved by 10 min hypoxia using 95% N-2 + 5% CO2 followed by 10 min reoxygenation with 100% oxygen. Whole body hypoxic preconditioning (HP) cycles were performed with 3 min hypoxia and 5 min reoxygenation. Thirty-three pups were randomly allocated into 4 groups. Group 1 served as untreated controls. The pups in group 2 were subjected to H/R only. In groups 3 and 4, 1 cycle and 3 cycles of HP were performed prior to H/R, respectively. Animals were killed at the end of the protocols. Intestine specimens were obtained to determine the histological changes, as well as to measure the tissue malondialdehyde (MDA) and nitric oxide (NO) levels, and xanthine oxidase (XO) and myeloperoxidase (MPO) activities. Results: The microscopic lesions in H/R rat pups were virtually the same as those seen in neonatal NEC, with severe destruction of villi and crypts, in some cases extending to the muscularis. In both HP groups, the lesions were found to be milder. H/R resulted in a marked elevation in MDA and NO levels, and XO and MPO activities compared to the untreated controls. Both 1 cycle and 3 cycles of HP prior to H/R resulted in an obvious decrease in all biochemical parameters. Differences of the biochemical results between both HP groups were not statistically significant. Conclusion: This study revealed that whole-body hypoxic preconditioning is beneficial for hypoxia/reoxygenation-induced intestinal injury in newborn rats.

2005-01-01T00:00:00Z Cinemre, Fatma Behice https://hdl.handle.net/20.500.12619/65681 2020-02-27T07:23:56Z 2004-01-01T00:00:00Z

Cytochrome c release is required for phosphatidylserine peroxidation during fas-triggered apoptosis in lung epithelial A549 cells Cinemre, Fatma Behice

2004-01-01T00:00:00Z