Browsing by Subject "beta-lactam"

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Genotoxicity evaluation of a new phthalazine substituted beta-lactam derivative in human lymphocytes

Aygun, Betul; Berber, Ahmet A.; Doganci, Merve A.; Berber, Nurcan; Sen, Selen; Yildiz, Esra; Aksoy, Huseyin (ACAD BRASILEIRA DE CIENCIAS, 2022)

The aim of present study, to evaluate the genotoxic potential of 1-(4-(3,3-dimethyl-1,6-dioxo-2,3,4,6,11,13-hexahydro-1H-indazolo[1,2b] phthalazine-13yl) phenyl)-2-phenylazetidine-3-yl-acetate which was synthesised assuming ...
Novel beta-lactam substituted benzenesulfonamides: in vitro enzyme inhibition, cytotoxic activity and in silico interactions

Gulec, Ozcan; Turkes, Cuneyt; Arslan, Mustafa; Demir, Yeliz; Dincer, Busra; Ece, Abdulilah; Beydemir, Sukru (TAYLOR & FRANCIS INC, 2023)

In this study, a library of twelve beta-lactam-substituted benzenesulfonamides (5a-l) was synthesized using the tail-approach method. The compounds were characterized using IR, H-1 NMR, C-13 NMR and elemental analysis ...