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Browsing by Subject "Genetics & Heredity"

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Genetic polymorphism in sex hormone metabolism and prostate cancer risk

Halis, Fikret (FUNPEC-EDITORA, 2015)

We compared single-nucleotide polymorphisms for point mutations in cytochrome P450 genes, including cytochrome P450c17 alpha (CYP17), cytochrome P450 aromatase (CYP19), steroid-5-alpha-reductase (SRD5A2), and prostate-specific ...
Identification of CHEK2 Germline Mutations in BRCA1/2- and PALB2-Negative Breast and Ovarian Cancer Patients

Aksoy, Fuat; Tezcan Unlu, Havva; Cecener, Gulsah; Guney Eskiler, Gamze; Egeli, Unal; Tunca, Berrin; Efendi Erdem, Ecem; Senol, Kazim; Gokgoz, Mustafa Sehsuvar (KARGER, 2022)

Introduction: The CHEK2 gene is known to be an important signal transducer involved in DNA repair, apoptosis, or cell cycle arrest in response to DNA damage. The mutations in this gene have been associated with a wide range ...
Identification of the molecular etiology in congenital hemolytic anemias beyond hemoglobinopathies using a targeted next-generation sequencing panel

Atik, Tahir; Isik, Esra; Aydinok, Yesim; Orhan, Mehmet Fatih; Oymak, Yesim; Karakas, Zeynep; Sarper, Nazan; Albayrak, Canan; Karadas, Nihal (2022)
MBL2 Gene Polymorphism and Risk of Vitiligo in Turkish Patients

Solak, Berna; Erdem, Mustafa Teoman (KAMLA-RAJ ENTERPRISES, 2015)

Mannose-Binding Lectin (MBL) plays an important role in innate immunity. MBL2 gene polymorphisms affect MBL serum levels. Therefore, this increases the risk of infection and may result in predisposition to autoimmune ...
Mutations in XRCC4 cause primary microcephaly, short stature and increased genomic instability

Nadine Rosin; Nursel H. Elcioglu; Filippo Beleggia; İşgüven, Şükriye Pınar; Janine Altmueller; Holger Thiele; Katharina Steindl; Pascal Joset; Anita Rauch; Peter Nuernberg; Bernd Wollnik; Goekhan Yigit (OXFORD UNIV PRESS, 2015)

DNA double-strand breaks (DSBs) are highly toxic lesions, which, if not properly repaired, can give rise to genomic instability. Non-homologous end-joining (NHEJ), a well-orchestrated, multistep process involving numerous ...
The Investigation of the Cytotoxic Effects of Some Pesticides on Soybean (Glycine max L.)

Deveci Özkan, Asuman (UNIV TOKYO CYTOLOGIA, 2012)

In this study, the effects of the fungicide Pomarsol Forte WP 80, the insecticide Arrivo 25 EC and the herbicide The End EC were examined for seed germination percentages, the phases of mitosis and chromosomal abnormalities ...