Browsing by Subject "Early-onset breast cancer"

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Identification of CHEK2 Germline Mutations in BRCA1/2- and PALB2-Negative Breast and Ovarian Cancer Patients

Aksoy, Fuat; Tezcan Unlu, Havva; Cecener, Gulsah; Guney Eskiler, Gamze; Egeli, Unal; Tunca, Berrin; Efendi Erdem, Ecem; Senol, Kazim; Gokgoz, Mustafa Sehsuvar (KARGER, 2022)

Introduction: The CHEK2 gene is known to be an important signal transducer involved in DNA repair, apoptosis, or cell cycle arrest in response to DNA damage. The mutations in this gene have been associated with a wide range ...