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Browsing by Author "Ozkan, Asuman Deveci"

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Anticancer Properties of Eisenia Foetida Proteins in Prostate Cancer Cells In Vitro

Ozkan, Asuman Deveci; Eskiler, Gamze Guney; Sarihan, Mehmet; Kazan, Nur; Aksoy, Ozlem; Yuksel, Burcu; Betts, Zeynep (2022)

Earthworms are tube-shaped, segmental worms and have a double transport system consisting of earthworm coelomic fluid (ECF) moving within the fluid-filled colon. As one of the naturally available extracts (NAEs), ECF exerts ...
Association between the anticancer efficacy of cabazitaxel and toll-like receptor 4 mediating signaling pathways in metastatic castration-resistant prostate cancer cells

Guney Eskiler, Gamze; Ozkan, Asuman Deveci; Eryilmaz, Isil Ezgi; Egeli, Unal; Cecener, Gulsah (SAGE PUBLICATIONS LTD, )

Background: We evaluated the effect of cabazitaxel (CAB) as a third-line taxane on Toll-like receptor 4 (TLR4)-mediated signaling pathways, especially NF-kappa B activity, in metastatic castration-resistant prostate cancer ...
Effect of the MiR-99b and MiR-135b on peritoneal carcinomatosis and liver metastasis in colorectal cancer

Aziret, Mehmet; Eskiler, Gamze Guney; Cakar, Gozde Cakirsoy; Ozkan, Asuman Deveci; Ercan, Metin; Bilir, Cemil; Polat, Erdal; Kocer, Havva Belma; Yildirim, Ebru Kayra; Duman, Mustafa (ELSEVIER ESPANA, 2023)

Aim: This study aimed to evaluate the expression levels of miR-99b and miR-135b in peritoneal carcinoma and liver metastases associated with Colorectal Cancer (CRC), assess their association with the intracellular signaling ...
Efficacy of 5-aminolevulinic acid-based photodynamic therapy in different subtypes of canine mammary gland cancer cells

Turna, Ozge; Baykal, Aslihan; Kucukkara, Elif Sozen; Ozten, Ozge; Ozkan, Asuman Deveci; Eskiler, Gamze Guney; Kamanli, Ali Furkan; Bilir, Cemil; Yildiz, Salih Zeki; Kaleli, Suleyman; Ucmak, Melih; Kasikci, Guven; Lim, Hyun Soo (SPRINGER LONDON LTD, 2021)

Canine mammary gland tumors (CMGTs) are heterogeneous disease and subclassified [sarcomas (S), carcinomas (C), and carcinosarcomas (CS)] according to histopathological differentiation. Photodynamic therapy (PDT) is a ...
Evaluation of the antioxidative and genotoxic effects of sodium butyrate on breast cancer cells

Yuksel, Burcu; Ozkan, Asuman Deveci; Aydin, Duygu; Betts, Zeynep (ELSEVIER, 2022)

Oncogenic stimulation shows a rise in reactive oxygen species (ROS), and ROS can eventually induce carcinogenesis by causing DNA damage. In this context, this study aims to evaluate some biochemical and genotoxic changes ...
Evaluation of the Effects of Nobiletin on Toll-Like Receptor 3 Signaling Pathways in Prostate Cancer In Vitro

Ozkan, Asuman Deveci; Sarihan, Mehmet; Kaleli, Suleyman (ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, )

Nobiletin as a nontoxic dietary citrus flavonoid has anticancer effects in cancer. Toll-like receptor three has a role in prostate cancer progression. However the relationship among NOB and TLR3 signaling in PCa has not ...
Fabrication of dopamine conjugated with protein @metal organic framework for targeted drug delivery: A biocompatible pH-Responsive nanocarrier for gemcitabine release on MCF-7 human breast cancer cells

Abd Al-jabbar, Shatha; Atiroglu, Vesen; Hameed, Rana M.; Eskiler, Gamze Guney; Atiroglu, Atheer; Ozkan, Asuman Deveci; Ozacar, Mahmut (2022)

Metal-organic structures (MOF), modern extremely proliferous materials consisting of metal ions and organic coordinating molecules, has become a promising biomedical material because of its unusual features, including great ...
In vitro chemo-protective effect of Eisenia foetida coelomic fluid against histone deacetylase inhibitor-induced oxidative toxicity in breast cancer cells

Ozkan, Asuman Deveci; Alimudin, Janiah; Kilciler, Yasemin; Yuksel, Burcu; Aksoy, Ozlem; Betts, Zeynep (2022)

Developing new drugs from natural products is important for therapeutic effects to minimise tissue toxicity of drugs used in cancer treatment. Eisenia foetida is a worm with a double transport system consisting of coelomic ...
Investigation of LED-based photodynamic therapy efficiency on breast cancer cells

Kamanli, Ali Furkan; Yildiz, Mustafa Zahid; Ozyol, Ebru; Ozkan, Asuman Deveci; Kucukkara, Elif Sozen; Eskiler, Gamze Guney (SPRINGER LONDON LTD, 2021)

Photodynamic therapy (PDT) is based on special light source, photosensitizer (PS), and in the presence of oxygen. Different light sources have been used for PDT applications. Recent studies have focused on LED light sources ...
Optimization of 5-aminolevulinic acid-based photodynamic therapy protocol for breast cancer cells

Eskiler, Gamze Guney; Ozkan, Asuman Deveci; Kucukkara, Elif Sozen; Kamanli, Ali Furkan; Gunoglu, Busra; Yildiz, Mustafa Zahid (ELSEVIER, 2020)

Background: Photodynamic therapy (PDT) is a therapeutic strategy for the treatment of cancer. 5-aminolevulinic acid (5-ALA) as a precursor of the protoporphyrin IX (PpIX) has a great potential for PDT application. Although ...
Protective effect of Eisenia foetida coelomic fluid against oxidative damage in human endothelial cells

Kilciler, Yasemin; Ozkan, Asuman Deveci; Betts, Zeynep (2022)

The protective effect of Eisenia foetida coelomic fluid on hydrogen peroxide-induced oxidative damage and cell death was determined at gene and protein levels. The coelomic fluid protects viability and cell morphology in ...
The Predictive Role of MMP-2, MMP-9, TIMP-1 and TIMP-2 Serum Levels in the Complete Response of the Tumor to Chemotherapy in Breast Cancer Patients

Ozdemir, Kayhan; Zengin, Ismail; Eskiler, Gamze Guney; Kocer, Havva Belma; Ozkan, Asuman Deveci; Demiray, Tayfur; Sahin, Elif Ozozen (2022)

Objective We investigated the serum levels of MMPs and TIMPs in breast cancer (BC) patients to predict the response rate to/after treatment with or without neoadjuvant chemotherapy. BC is the most common cancer in women ...
The relationship between the efficacy of talazoparib and the functional toll-like receptors 3 and 9 in triple negative breast cancer

Eskiler, Gamze Guney; Ozkan, Asuman Deveci (2022)

Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) induce cell death by inhibiting the repair of DNA strand breaks binding to PARP and regulate immune cells functions. Toll-like receptors (TLRs) mediate the tumor ...
The response of the canine mammary simple carcinoma and carcinosarcoma cells to 5-aminolaevulinic acid-based photodynamic therapy: An in vitro study

Eskiler, Gamze Guney; Turna, Ozge; Ozkan, Asuman Deveci; Baykal, Aslihan; Gurgen, Hazal Ozturk; Erk, Beyzanur; Armutak, Elif Ilkay; Lim, Hyun Soo (2022)

Backgrounds: Canine mammary gland tumors (CMGTs) are heterogeneous tumors and share many similar features with human breast cancer. Despite the improvement of current treatment options, new treatment modalities are required ...